2XEF
Human glutamate carboxypeptidase II in complex with Antibody- Recruiting Molecule ARM-P8
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GLUTAMATE CARBOXYPEPTIDASE 2 | polymer | 709 | 79874.0 | 1 | UniProt (Q04609) Pfam (PF02225) Pfam (PF04389) Pfam (PF04253) | HOMO SAPIENS (HUMAN) | GLUTAMATE CARBOXYPEPTIDASE II, MEMBRANE GLUTAMATE CARBOXYPEPTIDASE, GCPII, N-ACETYLATED -ALPHA-LINKED ACIDIC DIPEPTIDASE I, NAALADASE I, PTEROYLPOLY-GAMMA-GLUTAMATE CARBOXYPEPTIDASE, FOLYLPOLY-GAMMA-GLUTAMATE CARBOXYPEPTIDASE, MGCP, FGCP, FOLATE HYDROLASE 1, PROSTATE-SPECIFIC MEMBRANE ANTIGEN, PSMA, PSM, CELL GROWTH-INHIBITING GENE 27 PROTEIN |
| 2 | B, C, D (B, C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 3 | E (E) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
| 4 | F (A) | N-{[(1S)-5-{4-[25-({2,4-BIS[HYDROXY(OXO)AMMONIO]PHENYL}AMINO)-2,5,8,11,14,17,20,23-OCTAOXAPENTACOS-1-YL]-1H-1,2,3-TRIAZOL-1-YL}-1-CARBOXYPENTYL]CARBAMOYL}-L-GLUTAMIC ACID | non-polymer | 920.9 | 1 | Chemie (AR8) | |||
| 5 | G, H (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | I (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 7 | J (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | K, L, M (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 9 | N (A) | water | water | 18.0 | 581 | Chemie (HOH) |
Sequence modifications
A: 44 - 750 (UniProt: Q04609)
| PDB | External Database | Details |
|---|---|---|
| Arg 42 | - | expression tag |
| Ser 43 | - | expression tag |
| Gln 593 | Leu 593 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 79874.0 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2021.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1790.9 | |
| All* | Total formula weight | 83686.8 |
