2XEF

Human glutamate carboxypeptidase II in complex with Antibody- Recruiting Molecule ARM-P8

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	GLUTAMATE CARBOXYPEPTIDASE 2	polymer	709	79874.0	1	UniProt (Q04609) Pfam (PF02225) Pfam (PF04389) Pfam (PF04253) In PDB	HOMO SAPIENS (HUMAN)	GLUTAMATE CARBOXYPEPTIDASE II, MEMBRANE GLUTAMATE CARBOXYPEPTIDASE, GCPII, N-ACETYLATED -ALPHA-LINKED ACIDIC DIPEPTIDASE I, NAALADASE I, PTEROYLPOLY-GAMMA-GLUTAMATE CARBOXYPEPTIDASE, FOLYLPOLY-GAMMA-GLUTAMATE CARBOXYPEPTIDASE, MGCP, FGCP, FOLATE HYDROLASE 1, PROSTATE-SPECIFIC MEMBRANE ANTIGEN, PSMA, PSM, CELL GROWTH-INHIBITING GENE 27 PROTEIN
2	B, C, D	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
3	E	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
4	A	N-{[(1S)-5-{4-[25-({2,4-BIS[HYDROXY(OXO)AMMONIO]PHENYL}AMINO)-2,5,8,11,14,17,20,23-OCTAOXAPENTACOS-1-YL]-1H-1,2,3-TRIAZOL-1-YL}-1-CARBOXYPENTYL]CARBAMOYL}-L-GLUTAMIC ACID	non-polymer		920.9	1	Chemie (AR8)
5	A	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6	A	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
7	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
8	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
9		water	water		18.0	581	Chemie (HOH)

Sequence modifications

A: 44 - 750 (UniProt: Q04609)

PDB	External Database	Details
Arg 42	-	expression tag
Ser 43	-	expression tag
Gln 593	Leu 593	conflict

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	79874.0
Branched	Number of molecules	4
	Total formula weight	2021.9
Non-Polymers*	Number of molecules	8
	Total formula weight	1790.9
All*	Total formula weight	83686.8

*Water molecules are not included.