2XA7
AP2 clathrin adaptor core in active complex with cargo peptides
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ADAPTOR-RELATED PROTEIN COMPLEX 2, ALPHA 2 SUBUNIT | polymer | 621 | 69656.3 | 1 | UniProt (Q66HM2) Pfam (PF01602) UniProt (by SIFTS) (P18484) | RATTUS NORVEGICUS (RAT) | AP2 |
| 2 | B (B) | AP-2 COMPLEX SUBUNIT BETA | polymer | 592 | 67091.3 | 1 | UniProt (P63010) Pfam (PF01602) | HOMO SAPIENS (HUMAN) | ADAPTER-RELATED PROTEIN COMPLEX 2 BETA SUBUNIT, ADAPTOR PROTEIN COMPLEX AP-2 SUBUNIT BETA, BETA-2-ADAPTIN, BETA-ADAPTIN, PLASMA MEMBRANE ADAPTOR HA2/AP2 ADAPTIN BETA SUBUNIT, CLATHRIN ASSEMBLY PROTEIN COMPLEX 2 BETA LARGE CHAIN, AP105B, AP2 |
| 3 | C (M) | AP-2 COMPLEX SUBUNIT MU, | polymer | 446 | 51044.1 | 1 | UniProt (P84092) Pfam (PF01217) Pfam (PF00928) | RATTUS NORVEGICUS (RAT) | ADAPTER-RELATED PROTEIN COMPLEX 2 MU SUBUNIT, ADAPTOR PROTEIN COMPLEX AP-2 SUBUNIT MU, MU2-ADAPTIN AP-2 MU CHAIN, PLASMA MEMBRANE ADAPTOR AP-2 50 KDA PROTEIN, CLATHRIN ASSEMBLY PROTEIN COMPLEX 2 MEDIUM CHAIN, CLATHRIN COAT ASSEMBLY PROTEIN AP50, CLATHRIN COAT-ASSOCIATED PROTEIN AP50, AP2 |
| 4 | D (P) | TGN38 CARGO PEPTIDE | polymer | 6 | 808.9 | 1 | HOMO SAPIENS | ||
| 5 | E (S) | AP-2 COMPLEX SUBUNIT SIGMA | polymer | 142 | 17038.7 | 1 | UniProt (P62743) Pfam (PF01217) | MUS MUSCULUS (MOUSE) | ADAPTER-RELATED PROTEIN COMPLEX 2 SIGMA SUBUNIT, ADAPTOR PROTEIN COMPLEX AP-2 SUBUNIT SIGMA, SIGMA2-ADAPTIN, SIGMA-ADAPTIN 3B, PLASMA MEMBRANE ADAPTOR AP-2 17 KDA PROTEIN, CLATHRIN ASSEMBLY PROTEIN 2 SMALL CHAIN, CLATHRIN COAT ASSEMBLY PROTEIN AP17, CLATHRIN COAT-ASSOCIATED PROTEIN AP17 |
| 6 | F, G, H, I, J (A, S) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) |
Sequence modifications
M: 248 - 446 (UniProt: P84092)
| PDB | External Database | Details |
|---|---|---|
| Met 237 | - | insertion |
| Glu 238 | - | insertion |
| Gln 239 | - | insertion |
| Lys 240 | - | insertion |
| Leu 241 | - | insertion |
| Ile 242 | - | insertion |
| Ser 243 | - | insertion |
| Glu 244 | - | insertion |
| Glu 245 | - | insertion |
| Asp 246 | - | insertion |
| Leu 247 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 205639.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 480.3 | |
| All* | Total formula weight | 206119.6 |
