2XA7
AP2 clathrin adaptor core in active complex with cargo peptides
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0006886 | biological_process | intracellular protein transport |
| A | 0016192 | biological_process | vesicle-mediated transport |
| A | 0030117 | cellular_component | membrane coat |
| A | 0030121 | cellular_component | AP-1 adaptor complex |
| B | 0006886 | biological_process | intracellular protein transport |
| B | 0015031 | biological_process | protein transport |
| B | 0016192 | biological_process | vesicle-mediated transport |
| B | 0030117 | cellular_component | membrane coat |
| B | 0030276 | molecular_function | clathrin binding |
| M | 0006886 | biological_process | intracellular protein transport |
| M | 0016192 | biological_process | vesicle-mediated transport |
| M | 0030131 | cellular_component | clathrin adaptor complex |
| S | 0005515 | molecular_function | protein binding |
| S | 0005737 | cellular_component | cytoplasm |
| S | 0005886 | cellular_component | plasma membrane |
| S | 0005905 | cellular_component | clathrin-coated pit |
| S | 0006886 | biological_process | intracellular protein transport |
| S | 0006897 | biological_process | endocytosis |
| S | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| S | 0015031 | biological_process | protein transport |
| S | 0016192 | biological_process | vesicle-mediated transport |
| S | 0030117 | cellular_component | membrane coat |
| S | 0030122 | cellular_component | AP-2 adaptor complex |
| S | 0035615 | molecular_function | clathrin adaptor activity |
| S | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| S | 0045202 | cellular_component | synapse |
| S | 0048488 | biological_process | synaptic vesicle endocytosis |
| S | 0071944 | cellular_component | cell periphery |
| S | 0072583 | biological_process | clathrin-dependent endocytosis |
| S | 0098794 | cellular_component | postsynapse |
| S | 0098884 | biological_process | postsynaptic neurotransmitter receptor internalization |
| S | 0098894 | cellular_component | extrinsic component of presynaptic endocytic zone membrane |
| S | 0098978 | cellular_component | glutamatergic synapse |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1622 |
| Chain | Residue |
| A | ARG21 |
| S | ARG15 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1623 |
| Chain | Residue |
| A | ASP382 |
| A | VAL383 |
| A | SER384 |
| S | ARG42 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 S 1143 |
| Chain | Residue |
| B | LYS45 |
| S | ASP43 |
| S | ALA44 |
| S | ARG61 |
| B | LYS12 |
| B | GLY13 |
| B | ILE15 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1624 |
| Chain | Residue |
| A | HIS527 |
| A | VAL562 |
| A | SER565 |
| A | SER567 |
| A | GLN568 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 S 1144 |
| Chain | Residue |
| S | ASN48 |
| S | ARG60 |
| S | ARG61 |
Functional Information from PROSITE/UniProt
| site_id | PS00989 |
| Number of Residues | 11 |
| Details | CLAT_ADAPTOR_S Clathrin adaptor complexes small chain signature. IIYRryagLYF |
| Chain | Residue | Details |
| S | ILE57-PHE67 |
| site_id | PS00990 |
| Number of Residues | 21 |
| Details | CLAT_ADAPTOR_M_1 Clathrin adaptor complexes medium chain signature 1. IGWRre.GikYrrNeLFLDVLE |
| Chain | Residue | Details |
| M | ILE159-GLU179 |
| site_id | PS00991 |
| Number of Residues | 15 |
| Details | CLAT_ADAPTOR_M_2 Clathrin adaptor complexes medium chain signature 2. IsFIPPdGeFeLmrY |
| Chain | Residue | Details |
| M | ILE274-TYR288 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:12086608, ECO:0000305|PubMed:25061211, ECO:0007744|PDB:2VGL, ECO:0007744|PDB:4UQI |
| Chain | Residue | Details |
| A | LYS57 | |
| A | ARG11 | |
| A | LYS43 | |
| A | TYR53 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q96CW1 |
| Chain | Residue | Details |
| M | SER45 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q96CW1 |
| Chain | Residue | Details |
| M | THR156 |
