2XA7
AP2 clathrin adaptor core in active complex with cargo peptides
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005794 | cellular_component | Golgi apparatus |
A | 0006886 | biological_process | intracellular protein transport |
A | 0016192 | biological_process | vesicle-mediated transport |
A | 0030117 | cellular_component | membrane coat |
A | 0030121 | cellular_component | AP-1 adaptor complex |
B | 0006886 | biological_process | intracellular protein transport |
B | 0015031 | biological_process | protein transport |
B | 0016192 | biological_process | vesicle-mediated transport |
B | 0030117 | cellular_component | membrane coat |
B | 0030276 | molecular_function | clathrin binding |
M | 0006886 | biological_process | intracellular protein transport |
M | 0016192 | biological_process | vesicle-mediated transport |
M | 0030131 | cellular_component | clathrin adaptor complex |
S | 0005515 | molecular_function | protein binding |
S | 0005886 | cellular_component | plasma membrane |
S | 0005905 | cellular_component | clathrin-coated pit |
S | 0006886 | biological_process | intracellular protein transport |
S | 0006897 | biological_process | endocytosis |
S | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
S | 0015031 | biological_process | protein transport |
S | 0016192 | biological_process | vesicle-mediated transport |
S | 0030117 | cellular_component | membrane coat |
S | 0030122 | cellular_component | AP-2 adaptor complex |
S | 0035615 | molecular_function | clathrin adaptor activity |
S | 0045202 | cellular_component | synapse |
S | 0048488 | biological_process | synaptic vesicle endocytosis |
S | 0071944 | cellular_component | cell periphery |
S | 0072583 | biological_process | clathrin-dependent endocytosis |
S | 0098793 | cellular_component | presynapse |
S | 0098794 | cellular_component | postsynapse |
S | 0098884 | biological_process | postsynaptic neurotransmitter receptor internalization |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 A 1622 |
Chain | Residue |
A | ARG21 |
S | ARG15 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 1623 |
Chain | Residue |
A | ASP382 |
A | VAL383 |
A | SER384 |
S | ARG42 |
site_id | AC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 S 1143 |
Chain | Residue |
B | LYS45 |
S | ASP43 |
S | ALA44 |
S | ARG61 |
B | LYS12 |
B | GLY13 |
B | ILE15 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 1624 |
Chain | Residue |
A | HIS527 |
A | VAL562 |
A | SER565 |
A | SER567 |
A | GLN568 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 S 1144 |
Chain | Residue |
S | ASN48 |
S | ARG60 |
S | ARG61 |
Functional Information from PROSITE/UniProt
site_id | PS00989 |
Number of Residues | 11 |
Details | CLAT_ADAPTOR_S Clathrin adaptor complexes small chain signature. IIYRryagLYF |
Chain | Residue | Details |
S | ILE57-PHE67 |
site_id | PS00990 |
Number of Residues | 21 |
Details | CLAT_ADAPTOR_M_1 Clathrin adaptor complexes medium chain signature 1. IGWRre.GikYrrNeLFLDVLE |
Chain | Residue | Details |
M | ILE159-GLU179 |
site_id | PS00991 |
Number of Residues | 15 |
Details | CLAT_ADAPTOR_M_2 Clathrin adaptor complexes medium chain signature 2. IsFIPPdGeFeLmrY |
Chain | Residue | Details |
M | ILE274-TYR288 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000305|PubMed:12086608, ECO:0000305|PubMed:25061211, ECO:0007744|PDB:2VGL, ECO:0007744|PDB:4UQI |
Chain | Residue | Details |
A | ARG11 | |
A | LYS43 | |
A | TYR53 | |
A | LYS57 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q96CW1 |
Chain | Residue | Details |
M | SER45 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q96CW1 |
Chain | Residue | Details |
M | THR156 |