2X6F

THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH 3-METHYLADENINE

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	PHOSPHOTIDYLINOSITOL 3 KINASE 59F	polymer	696	78765.5	2	UniProt (Q9W1M7) Pfam (PF00613) Pfam (PF00454)	DROSOPHILA MELANOGASTER (FRUIT FLY)	GH13170P, VPS34
2	C, D (A, B)	6-AMINO-3-METHYLPURINE	non-polymer		150.2	2	Chemie (3MA)

Sequence modifications

A, B: 254 - 257 (PDB: 2X6F)
A, B: 258 - 949 (UniProt: Q9W1M7)

PDB	External Database	Details
Gly 254	-	expression tag
Ser 255	-	expression tag
His 256	-	expression tag
Met 257	-	expression tag
Ala 455	Gly 455	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	157530.9
Non-Polymers*	Number of molecules	2
	Total formula weight	300.3
All*	Total formula weight	157831.3

*Water molecules are not included.