2X50

Crystal structure of Trypanothione reductase from Leishmania infantum in complex with NADPH and silver

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	TRYPANOTHIONE REDUCTASE	polymer	510	55144.4	2	UniProt (A4HSF7) Pfam (PF07992) Pfam (PF02852)	LEISHMANIA INFANTUM
2	C, H (A, B)	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	2	Chemie (FAD)
3	D, K (A, B)	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	2	Chemie (NDP)
4	E, F, I, J (A, B)	SILVER ION	non-polymer		107.9	4	Chemie (AG)
5	G, L (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
6	M, N (A, B)	water	water		18.0	17	Chemie (HOH)

Sequence modifications

A, B: 1 - 490 (UniProt: A4HSF7)

PDB	External Database	Details
Met -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	110288.8
Non-Polymers*	Number of molecules	10
	Total formula weight	3685.5
All*	Total formula weight	113974.3

*Water molecules are not included.