2X4F

The Crystal Structure of the human myosin light chain kinase LOC340156.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4	polymer	373	42496.3	2	UniProt (Q86YV6) Pfam (PF00069)	HOMO SAPIENS (HUMAN)	SERINE/THREONINE-PROTEIN KINASE SGK085, SUGEN KINASE 85
2	C, H (A, B)	4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-dioxaziridin-3-ylphenyl)pyrimidin-2-amine	non-polymer		328.3	2	Chemie (16X)
3	D (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4	E (A)	PENTAETHYLENE GLYCOL	non-polymer		238.3	1	Chemie (1PE)
5	F, G, I (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
6	J, K (A, B)	water	water		18.0	252	Chemie (HOH)

Sequence modifications

A, B: 16 - 39 (PDB: 2X4F)
A, B: 40 - 388 (UniProt: Q86YV6)

PDB	External Database	Details
Met 16	-	expression tag
Gly 17	-	expression tag
His 18	-	expression tag
His 19	-	expression tag
His 20	-	expression tag
His 21	-	expression tag
His 22	-	expression tag
His 23	-	expression tag
Ser 24	-	expression tag
Ser 25	-	expression tag
Gly 26	-	expression tag
Val 27	-	expression tag
Asp 28	-	expression tag
Leu 29	-	expression tag
Gly 30	-	expression tag
Thr 31	-	expression tag
Glu 32	-	expression tag
Asn 33	-	expression tag
Leu 34	-	expression tag
Tyr 35	-	expression tag
Phe 36	-	expression tag
Gln 37	-	expression tag
Ser 38	-	expression tag
Met 39	-	expression tag
Ser 371	Asn 371	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	84992.5
Non-Polymers*	Number of molecules	7
	Total formula weight	1177.2
All*	Total formula weight	86169.8

*Water molecules are not included.