2X4D

Crystal structure of human phospholysine phosphohistidine inorganic pyrophosphate phosphatase LHPP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	PHOSPHOLYSINE PHOSPHOHISTIDINE INORGANIC PYROPHOSPHATE PHOSPHATASE	polymer	271	29085.2	2	UniProt (Q9H008) Pfam (PF13344) Pfam (PF13242) In PDB	HOMO SAPIENS (HUMAN)	HLHPP
2	A, B	PYROPHOSPHATE 2-	non-polymer		176.0	2	Chemie (POP)
3	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	A, B	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	2	Chemie (EPE)
5	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6		water	water		18.0	212	Chemie (HOH)

Sequence modifications

A, B: 0 - 0 (PDB: 2X4D)
A, B: 1 - 270 (UniProt: Q9H008)

PDB	External Database	Details
Arg 94	Gln 94	SEE REMARK 999
Ala 160	Lys 160	engineered mutation
Ala 161	Glu 161	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	58170.4
Non-Polymers*	Number of molecules	7
	Total formula weight	969.2
All*	Total formula weight	59139.6

*Water molecules are not included.