2WU6
Crystal Structure of the Human CLK3 in complex with DKI
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DUAL SPECIFICITY PROTEIN KINASE CLK3 | polymer | 381 | 44790.1 | 1 | UniProt (P49761) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | CDC-LIKE KINASE 3, CDC-LIKE KINASE 3 ISOFORM HCLK3 |
| 2 | B (A) | 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE | non-polymer | 425.4 | 1 | Chemie (DKI) | |||
| 3 | C, D, E (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | F, G, H (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 3 | Chemie (DMS) | |||
| 5 | I, J, K, L (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 6 | M, N, O (A) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 7 | P (A) | water | water | 18.0 | 307 | Chemie (HOH) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 44790.1 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1302.7 | |
| All* | Total formula weight | 46092.7 |
