2WU6

Crystal Structure of the Human CLK3 in complex with DKI

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE DKI A 1484

Chain	Residue
A	LEU162
A	GLU245
A	ASN288
A	LEU290
A	ALA319
A	HOH2090
A	HOH2292
A	HOH2293
A	HOH2294
A	VAL170
A	ALA184
A	VAL220
A	PHE236
A	GLU237
A	LEU239
A	GLY240
A	LYS241

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1485

Chain	Residue
A	ARG195
A	ARG199
A	LYS403
A	LYS405
A	HOH2295
A	HOH2296

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1486

Chain	Residue
A	ARG338
A	HIS377
A	HOH2297
A	HOH2298
A	HOH2299
A	HOH2300

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 1487

Chain	Residue
A	GLY192
A	ARG338
A	HOH2206
A	HOH2301
A	HOH2302
A	HOH2304
A	HOH2305

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 1488

Chain	Residue
A	HIS330
A	HIS331
A	LYS425
A	HOH2245
A	HOH2306

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 1489

Chain	Residue
A	HIS330
A	THR332
A	THR333
A	HOH2175
A	HOH2307

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DMS A 1490

Chain	Residue
A	ARG134
A	ARG272
A	HIS275
A	THR462
A	LEU463
A	ALA464
A	HOH2111
A	HOH2192

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1491

Chain	Residue
A	HIS339
A	GLN375
A	THR376
A	HIS377
A	ARG400
A	HOH2298

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1492

Chain	Residue
A	GLU378
A	ASN379
A	ARG380
A	LYS405
A	TYR406
A	HOH2232
A	HOH2302

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1493

Chain	Residue
A	LYS140
A	SER395
A	HIS396
A	HIS399

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1494

Chain	Residue
A	LYS140
A	PRO394
A	SER395
A	HIS396

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1495

Chain	Residue
A	ARG189
A	LYS193
A	TYR194

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1496

Chain	Residue
A	LYS206
A	TRP225

---

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1497

Chain	Residue
A	TRP414

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGTFGKVVeCldhargksq.........VALK

Chain	Residue	Details
A	LEU162-LYS186

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LtHtDLKpeNILF

Chain	Residue	Details
A	LEU279-PHE291

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	LEU431

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	SER310
A	ILE334

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	ARG155

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	GLU157

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	ALA197
A	ARG199

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	ASN215

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	ASP224
A	PHE226

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	ASP283

---