2WPK
factor IXa superactive triple mutant, ethylene glycol-soaked
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | E | COAGULATION FACTOR IXA LIGHT CHAIN | polymer | 59 | 6496.4 | 1 | UniProt (P00740) Pfam (PF14670) In PDB | HOMO SAPIENS (HUMAN) | HUMAN COAGULATION FACTOR IXA, CHRISTMAS FACTOR, PLASMA THROMBOPLASTIN COMPONENT, PTC |
| 2 | L | D-PHE-PRO-ARG-CHLOROMETHYL KETONE | polymer | 3 | 419.5 | 1 | BIRD (PRD_001148) | SYNTHETIC CONSTRUCT | |
| 3 | S | COAGULATION FACTOR IXA HEAVY CHAIN | polymer | 235 | 26084.7 | 1 | UniProt (P00740) Pfam (PF00089) In PDB | HOMO SAPIENS (HUMAN) | HUMAN COAGULATION FACTOR IXA, CHRISTMAS FACTOR, PLASMA THROMBOPLASTIN COMPONENT, PTC |
| 4 | S | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | S | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | water | water | 18.0 | 313 | Chemie (HOH) |
Sequence modifications
S: 16 - 245 (UniProt: P00740)
| PDB | External Database | Details |
|---|---|---|
| Phe 94 | Tyr 305 | engineered mutation |
| Thr 98 | Lys 311 | engineered mutation |
| Thr 177 | Tyr 391 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 33000.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 102.1 | |
| All* | Total formula weight | 33102.7 |
