2WPI
factor IXa superactive double mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | COAGULATION FACTOR IXA LIGHT CHAIN | polymer | 59 | 6496.4 | 1 | UniProt (P00740) Pfam (PF14670) | HOMO SAPIENS (HUMAN) | HUMAN COAGULATION FACTOR IXA, CHRISTMAS FACTOR, PLASMA THROMBOPLASTIN COMPONENT, PTC |
| 2 | B (L) | D-PHE-PRO-ARG-CHLOROMETHYL KETONE | polymer | 3 | 419.5 | 1 | BIRD (PRD_001148) | SYNTHETIC CONSTRUCT | |
| 3 | C (S) | COAGULATION FACTOR IXA HEAVY CHAIN | polymer | 235 | 26100.7 | 1 | UniProt (P00740) Pfam (PF00089) | HOMO SAPIENS (HUMAN) | HUMAN COAGULATION FACTOR IXA, CHRISTMAS FACTOR, PLASMA THROMBOPLASTIN COMPONENT, PTC |
| 4 | D (S) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | E, F, G (E, L, S) | water | water | 18.0 | 276 | Chemie (HOH) |
Sequence modifications
S: 16 - 245 (UniProt: P00740)
| PDB | External Database | Details |
|---|---|---|
| Thr 98 | Lys 311 | engineered mutation |
| Thr 177 | Tyr 391 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 33016.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 40.1 | |
| All* | Total formula weight | 33056.6 |
