2W3L

Crystal Structure of Chimaeric Bcl2-xL and Phenyl Tetrahydroisoquinoline Amide Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	APOPTOSIS REGULATOR BCL-2	polymer	144	16874.9	2	UniProt (P10415) Pfam (PF02180) Pfam (PF00452)	HOMO SAPIENS (HUMAN)	BCL2-XL
2	C, D (A, B)	1-(2-{[(3S)-3-(aminomethyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}phenyl)-4-chloro-5-methyl-N,N-diphenyl-1H-pyrazole-3-carboxamide	non-polymer		576.1	2	Chemie (DRO)
3	E, F (A, B)	water	water		18.0	223	Chemie (HOH)

Sequence modifications

A, B: 9 - 33 (UniProt: P10415)
A, B: 51 - 165 (UniProt: P10415)

PDB	External Database	Details
Lys 54	Leu 95	conflict
Glu 58	Gln 99	conflict
Gly 77	Gln 118	conflict

A, B: 34 - 50 (PDB: 2W3L)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	33749.9
Non-Polymers*	Number of molecules	2
	Total formula weight	1152.2
All*	Total formula weight	34902.0

*Water molecules are not included.