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2W3L

Crystal Structure of Chimaeric Bcl2-xL and Phenyl Tetrahydroisoquinoline Amide Complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0042981biological_processregulation of apoptotic process
B0042981biological_processregulation of apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE DRO A1166
ChainResidue
APHE63
ATYR67
AASP70
AMET74
AVAL92
AGLU95
ALEU96
AALA108
APHE112

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE DRO B1164
ChainResidue
BPHE63
BTYR67
BASP70
BPHE71
BMET74
BGLU95
BLEU96
BALA108
BPHE112
BHOH2102

Functional Information from PROSITE/UniProt
site_idPS01080
Number of Residues19
DetailsBH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFeFGG
ChainResidueDetails
ALEU96-GLY114

site_idPS01258
Number of Residues12
DetailsBH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqdnGGWDaFV
ChainResidueDetails
ATRP147-VAL158

site_idPS01259
Number of Residues15
DetailsBH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VhktLReAGDDFSRR
ChainResidueDetails
AVAL52-ARG66

site_idPS01260
Number of Residues21
DetailsBH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. DNREIVmKYIHYKLSQRGYeW
ChainResidueDetails
AASP10-TRP30

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Cleavage; by caspase-3
ChainResidueDetails
AALA34
BALA34

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by MAPK8 => ECO:0000269|PubMed:18570871
ChainResidueDetails
APRO82
BPRO82

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine; by MAPK8 and PKC => ECO:0000269|PubMed:18570871
ChainResidueDetails
APHE83
BPHE83

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine; by MAPK8 => ECO:0000269|PubMed:18570871
ChainResidueDetails
AGLY100
BGLY100

224572

PDB entries from 2024-09-04

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