2W3A
HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND TRIMETHOPRIM
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | DIHYDROFOLATE REDUCTASE | polymer | 187 | 21480.7 | 2 | UniProt (P00374) Pfam (PF00186) | HOMO SAPIENS (HUMAN) | |
| 2 | C, G (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 3 | D, H (A, B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 4 | E (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | F, I (A, B) | TRIMETHOPRIM | non-polymer | 290.3 | 2 | Chemie (TOP) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 408 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42961.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2351.7 | |
| All* | Total formula weight | 45313.2 |
