2W2M

WT PCSK9-DELTAC BOUND TO WT EGF-A OF LDLR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9	polymer	312	33108.2	1	UniProt (Q8NBP7) Pfam (PF00082) In PDB	HOMO SAPIENS (HUMAN)	PROPROTEIN CONVERTASE PC9, SUBTILISIN/KEXIN-LIKE PROTEASE PC9, NEURAL APOPTOSIS-REGULATED CONVERTASE 1, NARC-1, PCSK9
2	E	LOW-DENSITY LIPOPROTEIN RECEPTOR	polymer	107	12095.5	1	UniProt (P01130) In PDB	HOMO SAPIENS (HUMAN)	LDL RECEPTOR
3	P	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9	polymer	114	12679.6	1	UniProt (Q8NBP7) Pfam (PF05922) In PDB	HOMO SAPIENS (HUMAN)	PROPROTEIN CONVERTASE PC9, SUBTILISIN/KEXIN-LIKE PROTEASE PC9, NEURAL APOPTOSIS-REGULATED CONVERTASE 1, NARC-1, PCSK9
4	A, E	CALCIUM ION	non-polymer		40.1	3	Chemie (CA)
5		water	water		18.0	215	Chemie (HOH)

Sequence modifications

A: 153 - 451 (UniProt: Q8NBP7)

PDB	External Database	Details
Ala 452	-	expression tag
Gly 453	-	expression tag
Thr 454	-	expression tag
Ala 455	-	expression tag
Ala 456	-	expression tag
Ala 457	-	expression tag
Ser 458	-	expression tag
His 459	-	expression tag
His 460	-	expression tag
His 461	-	expression tag
His 462	-	expression tag
His 463	-	expression tag
His 464	-	expression tag

E: 293 - 372 (UniProt: P01130)

PDB	External Database	Details
Met 266	-	expression tag
Lys 267	-	expression tag
His 268	-	expression tag
His 269	-	expression tag
His 270	-	expression tag
His 271	-	expression tag
His 272	-	expression tag
His 273	-	expression tag
Pro 274	-	expression tag
Met 275	-	expression tag
Ser 276	-	expression tag
Asp 277	-	expression tag
Tyr 278	-	expression tag
Asp 279	-	expression tag
Ile 280	-	expression tag
Pro 281	-	expression tag
Thr 282	-	expression tag
Thr 283	-	expression tag
Glu 284	-	expression tag
Asn 285	-	expression tag
Leu 286	-	expression tag
Tyr 287	-	expression tag
Phe 288	-	expression tag
Gln 289	-	expression tag
Gly 290	-	expression tag
Ala 291	-	expression tag
Met 292	-	expression tag

P: 53 - 152 (UniProt: Q8NBP7)

PDB	External Database	Details
Met 39	-	expression tag
Lys 40	-	expression tag
Gly 41	-	expression tag
Ser 42	-	expression tag
Lys 43	-	expression tag
Gly 44	-	expression tag
Ser 45	-	expression tag
Lys 46	-	expression tag
Gly 47	-	expression tag
Ser 48	-	expression tag
Lys 49	-	expression tag
Pro 50	-	expression tag
Met 51	-	expression tag
Ser 52	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	57883.3
Non-Polymers*	Number of molecules	3
	Total formula weight	120.2
All*	Total formula weight	58003.5

*Water molecules are not included.