2W2H

Structural basis of transcription activation by the Cyclin T1-Tat-TAR RNA complex from EIAV

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	CYCLIN-T1	polymer	264	30843.4	2	UniProt (Q9XT26) Pfam (PF00134) Pfam (PF21797)	EQUUS CABALLUS (HORSE)	CYCT1, CYCLIN-T
2	C, D (C, D)	PROTEIN TAT	polymer	29	3493.1	2	UniProt (P20920) Pfam (PF00539)	EQUINE INFECTIOUS ANEMIA VIRUS	CYCLIN T1-TAT FUSION PROTEIN, TRANSACTIVATING REGULATORY PROTEIN, ETAT, E-TAT
3	E, F (R, S)	5'-R(*GP*CP*UP*CP*AP*GP*AP*UP*CP*UP *GP*CP*GP*GP*UP*CP*UP*GP*AP*GP*C)-3'	polymer	22	7027.2	2		EQUINE INFECTIOUS ANEMIA VIRUS	TAR RNA
4	G, H (A, R)	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
5	I, J (A, B)	water	water		18.0	6	Chemie (HOH)

Sequence modifications

A, B: 4 - 4 (PDB: 2W2H)
A, B: 5 - 267 (UniProt: Q9XT26)

PDB	External Database	Details
Arg 77	Gln 77	conflict
Thr 110	Ala 110	conflict
Trp 256	Arg 256	conflict

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	82727.3
Non-Polymers*	Number of molecules	2
	Total formula weight	109.9
All*	Total formula weight	82837.1

*Water molecules are not included.