2VXS

Structure of IL-17A in complex with a potent, fully human neutralising antibody

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	INTERLEUKIN-17A	polymer	137	15689.9	4	UniProt (Q16552) Pfam (PF06083)	HOMO SAPIENS (HUMAN)	IL-17A, IL-17, CYTOTOXIC T-LYMPHOCYTE- ASSOCIATED ANTIGEN 8, CTLA-8, INTERLEUKINE-17A
2	E, F, G, H (H, I, J, K)	FAB FRAGMENT	polymer	225	23671.5	4		HOMO SAPIENS (HUMAN)
3	I, J, K, L (L, M, N, O)	FAB FRAGMENT	polymer	216	23196.6	4		HOMO SAPIENS (HUMAN)
4	M, N, O, P, Q... (A, B, C, D, I...)	SULFATE ION	non-polymer		96.1	12	Chemie (SO4)
5	AA, BA, CA, DA, EA... (C, D, H, I, J...)	water	water		18.0	214	Chemie (HOH)

Sequence modifications

A, B, C, D: -4 - -4 (PDB: 2VXS)
A, B, C, D: -3 - 132 (UniProt: Q16552)

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	250231.7
Non-Polymers*	Number of molecules	12
	Total formula weight	1152.8
All*	Total formula weight	251384.5

*Water molecules are not included.