2VXS

Structure of IL-17A in complex with a potent, fully human neutralising antibody

Summary for 2VXS

Entry DOI	10.2210/pdb2vxs/pdb
Descriptor	INTERLEUKIN-17A, FAB FRAGMENT, SULFATE ION, ... (5 entities in total)
Functional Keywords	epitope, complex, antibody, secreted, cytokine, glycoprotein, interleukin-17
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Secreted: Q16552
Total number of polymer chains	12
Total formula weight	251384.50
Authors	Gerhardt, S.,Hargreaves, D.,Pauptit, R.A.,Davies, R.A.,Russell, C.,Welsh, F.,Tuske, S.J.,Coales, S.J.,Hamuro, Y.,Needham, M.R.C.,Langham, C.,Barker, W.,Bell, P.,Aziz, A.,Smith, M.J.,Dawson, S.,Abbott, W.M. (deposition date: 2008-07-09, release date: 2009-07-14, Last modification date: 2023-12-13)
Primary citation	Gerhardt, S.,Abbott, W.M.,Hargreaves, D.,Pauptit, R.A.,Davies, R.A.,Needham, M.R.,Langham, C.,Barker, W.,Aziz, A.,Snow, M.J.,Dawson, S.,Welsh, F.,Wilkinson, T.,Vaugan, T.,Beste, G.,Bishop, S.,Popovic, B.,Rees, G.,Sleeman, M.,Tuske, S.J.,Coales, S.J.,Hamuro, Y.,Russell, C. Structure of Il-17A in Complex with a Potent, Fully Human Neutralising Antibody. J.Mol.Biol., 394:905-, 2009 Cited by PubMed: 19835883 DOI: 10.1016/J.JMB.2009.10.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.63 Å)

Structure validation