2VQJ
Structure of HDAC4 catalytic domain bound to a trifluoromethylketone inhbitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | HISTONE DEACETYLASE 4 | polymer | 413 | 44477.4 | 1 | UniProt (P56524) Pfam (PF00850) In PDB | HOMO SAPIENS (HUMAN) | HD4 |
2 | A | 1,4-DIETHYLENE DIOXIDE | non-polymer | 88.1 | 1 | Chemie (DIO) | |||
3 | A | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
4 | A | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
5 | A | 2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL)CARBONYL]THIOPHEN-2-YL}ETHANE-1,1-DIOL | non-polymer | 423.4 | 1 | Chemie (TFG) | |||
6 | A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
7 | water | water | 18.0 | 222 | Chemie (HOH) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 44477.4 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 1008.7 | |
All* | Total formula weight | 45486.1 |