2VQJ
Structure of HDAC4 catalytic domain bound to a trifluoromethylketone inhbitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HISTONE DEACETYLASE 4 | polymer | 413 | 44477.4 | 1 | UniProt (P56524) Pfam (PF00850) | HOMO SAPIENS (HUMAN) | HD4 |
| 2 | B (A) | 1,4-DIETHYLENE DIOXIDE | non-polymer | 88.1 | 1 | Chemie (DIO) | |||
| 3 | C, D (A) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 4 | E, F, G (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 5 | H (A) | 2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL)CARBONYL]THIOPHEN-2-YL}ETHANE-1,1-DIOL | non-polymer | 423.4 | 1 | Chemie (TFG) | |||
| 6 | I, J (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 7 | K (A) | water | water | 18.0 | 222 | Chemie (HOH) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 44477.4 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1008.7 | |
| All* | Total formula weight | 45486.1 |
