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2VQJ

Structure of HDAC4 catalytic domain bound to a trifluoromethylketone inhbitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0000118cellular_componenthistone deacetylase complex
A0004407molecular_functionhistone deacetylase activity
A0006325biological_processchromatin organization
A0016575biological_processhistone deacetylation
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE DIO A1408
ChainResidue
ATHR16
ALEU19
ALYS20

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE K A1409
ChainResidue
AASP194
AASP196
AHIS198
ASER217
ALEU218

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K A1410
ChainResidue
AASP210
AVAL213
APHE244
AHOH2114
AHOH2140
APHE207

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A1411
ChainResidue
AGLY36
AARG37
AILE38
AARG154
AHOH2222

site_idAC5
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A1412
ChainResidue
APRO256
AGLY318
AASN366
AALA367
AHOH2183
AHOH2223
AHOH2224
AHOH2225

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A1413
ChainResidue
ASER72
AGLU73
AHOH2042

site_idAC7
Number of Residues17
DetailsBINDING SITE FOR RESIDUE TFG A1414
ChainResidue
ALEU78
ATYR79
AALA124
APRO156
AHIS158
AHIS159
AGLY167
APHE168
AASP196
AHIS198
APHE227
AASP290
AGLU329
AGLY330
AZN1415
AHOH2226
AHOH2227

site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A1415
ChainResidue
AASP196
AHIS198
AASP290
ATFG1414

site_idAC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A1416
ChainResidue
AHIS21
ACYS23
AHIS34
ACYS107

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: ACT_SITE => ECO:0000250
ChainResidueDetails
AHIS159

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ACYS23
ACYS25
AHIS31
ACYS107

218853

PDB entries from 2024-04-24

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