2VP7

Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	PYGOPUS HOMOLOG 1	polymer	71	7661.5	1	UniProt (Q9Y3Y4) Pfam (PF00628) In PDB	HOMO SAPIENS (HUMAN)	HPYGO1
2	B	B-CELL CLL/LYMPHOMA 9 PROTEIN	polymer	33	3556.1	1	UniProt (O00512) In PDB	HOMO SAPIENS (HUMAN)	B-CELL LYMPHOMA 9 PROTEIN, BCL-9, PROTEIN LEGLESS HOMOLOG, BCL9
3	A, B	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
4	A	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5		water	water		18.0	99	Chemie (HOH)

Sequence modifications

A: 332 - 332 (PDB: 2VP7)
A: 333 - 402 (UniProt: Q9Y3Y4)

PDB	External Database	Details
Phe 366	Trp 366	engineered mutation

B: 173 - 173 (PDB: 2VP7)
B: 174 - 205 (UniProt: O00512)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	11217.7
Non-Polymers*	Number of molecules	5
	Total formula weight	419.0
All*	Total formula weight	11636.7

*Water molecules are not included.