2V92

Crystal structure of the regulatory fragment of mammalian AMPK in complexes with ATP-AMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1	polymer	157	17635.8	1	UniProt (P54645) Pfam (PF16579)	RATTUS NORVEGICUS (RAT)	AMPK ALPHA-1 CHAIN, AMP-ACTIVATED PROTEIN KINASE
2	B (B)	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2	polymer	87	10040.8	1	UniProt (O43741) Pfam (PF04739)	HOMO SAPIENS (HUMAN)	AMPK BETA-2 CHAIN, AMP-ACTIVATED PROTEIN KINASE
3	C (E)	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1	polymer	330	37434.1	1	UniProt (P80385) Pfam (PF00571)	RATTUS NORVEGICUS (RAT)	AMPK GAMMA-1 CHAIN, AMPKG, AMP-ACTIVATED PROTEIN KINASE
4	D, E (E)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)
5	F (E)	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	1	Chemie (AMP) PubChem (224) PubChem (34768) PubChem (83862) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (5316444) PubChem (5742864) PubChem (12163610) PubChem (12358355) PubChem (16397049) PubChem (16760266) PubChem (40467049) PubChem (40469468) PubChem (44348067) PubChem (45358029) PubChem (46874558) PubChem (40459109) PubChem (46875232) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (92144436) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (12358354) PubChem (122197642) PubChem (162290139) PubChem (162946266) PubChem (171699505)
6	G, H, I (A, B, E)	water	water		18.0	361	Chemie (HOH)

Sequence modifications

A: 392 - 395 (PDB: 2V92)
A: 396 - 548 (UniProt: P54645)
B: 186 - 186 (PDB: 2V92)
B: 187 - 272 (UniProt: O43741)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	65110.7
Non-Polymers*	Number of molecules	3
	Total formula weight	1361.6
All*	Total formula weight	66472.3

*Water molecules are not included.