2V8W

Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	polymer	217	25130.2	2	UniProt (P06730) Pfam (PF01652) In PDB	HOMO SAPIENS (HUMAN)	EIF4E, EIF-4E, MRNA CAP-BINDING PROTEIN, EIF-4F 25 KDA SUBUNIT
2	B, F	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1	polymer	14	1861.2	2	UniProt (Q13541) In PDB	HOMO SAPIENS	4E-BP1, EIF4E-BINDING PROTEIN 1, PHOSPHORYLATED HEAT- AND ACID-STABLE PROTEIN REGULATED BY INSULIN 1,
3	A, E	[[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE	non-polymer		537.2	2	Chemie (MGO)
4		water	water		18.0	302	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	53983.0
Non-Polymers*	Number of molecules	2
	Total formula weight	1074.5
All*	Total formula weight	55057.4

*Water molecules are not included.