2V2C
The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase (TIM) induces a more closed conformation of this hinge region in dimeric and monomeric TIM
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | TRIOSEPHOSPHATE ISOMERASE GLYCOSOMAL | polymer | 250 | 26907.9 | 1 | UniProt (P04789) Pfam (PF00121) | TRYPANOSOMA BRUCEI BRUCEI | TIM, TRIOSE- PHOSPHATE ISOMERASE |
| 2 | B, C, D (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 3 | E (A) | 2-PHOSPHOGLYCOLIC ACID | non-polymer | 156.0 | 1 | Chemie (PGA) | |||
| 4 | F (A) | water | water | 18.0 | 462 | Chemie (HOH) |
Sequence modifications
A: 1 - 250 (UniProt: P04789)
| PDB | External Database | Details |
|---|---|---|
| Leu 178 | Ala 178 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 26907.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 444.2 | |
| All* | Total formula weight | 27352.1 |
