2V1X

Crystal structure of human RECQ-like DNA helicase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	ATP-DEPENDENT DNA HELICASE Q1	polymer	591	67384.9	2	UniProt (P46063) Pfam (PF00270) Pfam (PF00271) Pfam (PF16124) In PDB	HOMO SAPIENS (HUMAN)	DNA-DEPENDENT ATPASE Q1, RECQ DNA HELICASE
2	A, B	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	2	Chemie (ADP)
3	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	A, B	CHLORIDE ION	non-polymer		35.5	9	Chemie (CL)
6	B	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
7		water	water		18.0	315	Chemie (HOH)

Sequence modifications

A, B: 49 - 616 (UniProt: P46063)

PDB	External Database	Details
Met 48	-	expression tag
Ala 617	-	expression tag
Glu 618	-	expression tag
Asn 619	-	expression tag
Leu 620	-	expression tag
Tyr 621	-	expression tag
Phe 622	-	expression tag
Gln 623	-	expression tag
Ser 624	-	expression tag
His 625	-	expression tag
His 626	-	expression tag
His 627	-	expression tag
His 628	-	expression tag
His 629	-	expression tag
His 630	-	expression tag
Asp 631	-	expression tag
Tyr 632	-	expression tag
Lys 633	-	expression tag
Asp 634	-	expression tag
Asp 635	-	expression tag
Asp 636	-	expression tag
Asp 637	-	expression tag
Lys 638	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	134769.9
Non-Polymers*	Number of molecules	17
	Total formula weight	1477.0
All*	Total formula weight	136246.9

*Water molecules are not included.