2V1D
Structural basis of LSD1-CoREST selectivity in histone H3 recognition
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | LYSINE-SPECIFIC HISTONE DEMETHYLASE 1 | polymer | 730 | 81279.4 | 1 | UniProt (O60341) Pfam (PF04433) Pfam (PF01593) | HOMO SAPIENS (HUMAN) | FLAVIN-CONTAINING AMINE OXIDASE DOMAIN-CONTAINING PROTEIN 2, BRAF35-HDAC COMPLEX PROTEIN BHC110 |
| 2 | B (B) | REST COREPRESSOR 1 | polymer | 178 | 20244.8 | 1 | UniProt (Q9UKL0) Pfam (PF20878) Pfam (PF00249) | HOMO SAPIENS (HUMAN) | PROTEIN COREST, COREST |
| 3 | C (C) | HISTONE H3.1T | polymer | 21 | 2263.7 | 1 | UniProt (Q16695) | HOMO SAPIENS | HISTONE H3 K4M PEPTIDE |
| 4 | D (A) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 1 | Chemie (FAD) |
Sequence modifications
C: 1 - 21 (UniProt: Q16695)
| PDB | External Database | Details |
|---|---|---|
| Met 4 | Lys 5 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 103787.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 785.5 | |
| All* | Total formula weight | 104573.5 |
