2V1D

Structural basis of LSD1-CoREST selectivity in histone H3 recognition

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0016491	molecular_function	oxidoreductase activity
A	0050660	molecular_function	flavin adenine dinucleotide binding
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0030527	molecular_function	structural constituent of chromatin

Functional Information from PDB Data

site_id	AC1
Number of Residues	30
Details	BINDING SITE FOR RESIDUE FAD A 1837

Chain	Residue
A	GLY285
A	ARG316
A	LEU329
A	GLY330
A	ALA331
A	MET332
A	VAL333
A	THR588
A	VAL590
A	THR624
A	LEU625
A	GLY287
A	PRO626
A	TRP756
A	SER760
A	TYR761
A	GLY800
A	GLU801
A	ALA809
A	THR810
A	VAL811
A	ALA814
A	VAL288
C	MET4
A	SER289
A	LEU307
A	GLU308
A	ALA309
A	ARG310
A	GLY315

---

Functional Information from PROSITE/UniProt

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
C	LYS14-LEU20

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Citrulline; alternate => ECO:0000250|UniProtKB:P84243

Chain	Residue	Details
C	ARG2
C	ARG17
A	ARG310
A	ARG316
A	MET332
A	GLU801
A	THR810

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by HASPIN => ECO:0000250|UniProtKB:P68431

Chain	Residue	Details
C	THR3

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P68431

Chain	Residue	Details
C	MET4
C	LYS18

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000250|UniProtKB:P68431

Chain	Residue	Details
C	GLN5

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PKC => ECO:0000250|UniProtKB:P68431

Chain	Residue	Details
C	THR6
C	THR11

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433

Chain	Residue	Details
C	ARG8

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P68432

Chain	Residue	Details
C	LYS9
A	LYS433
A	LYS436

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000250|UniProtKB:P68432

Chain	Residue	Details
C	SER10

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P68431

Chain	Residue	Details
C	LYS14

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS442
A	LYS469

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:25018020

Chain	Residue	Details
A	LYS503

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1f8r

Chain	Residue	Details
A	THR335

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1f8r

Chain	Residue	Details
A	LYS661
A	HIS551

---