2ROR

Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Proto-oncogene vav	polymer	138	15496.4	1	UniProt (P15498) Pfam (PF00017) In PDB	Homo sapiens (human)
2	B	15-meric peptide from Lymphocyte cytosolic protein 2	polymer	15	1793.5	1	UniProt (Q13094) In PDB		SH2 domain-containing leukocyte protein of 76 kDa, SLP-76 tyrosine phosphoprotein, SLP76

Sequence modifications

A: 8 - 132 (UniProt: P15498)

PDB	External Database	Details
Gly 1	-	expression tag
Ser 2	-	expression tag
Ser 3	-	expression tag
Gly 4	-	expression tag
Ser 5	-	expression tag
Ser 6	-	expression tag
Gly 7	-	expression tag
-	Gly 639	SEE REMARK 999
-	Arg 640	SEE REMARK 999
-	Asn 641	SEE REMARK 999
-	Thr 642	SEE REMARK 999
-	Ser 643	SEE REMARK 999
-	Thr 644	SEE REMARK 999
-	Asn 645	SEE REMARK 999
-	Glu 646	SEE REMARK 999
-	Ile 647	SEE REMARK 999
-	Gly 648	SEE REMARK 999
-	Trp 649	SEE REMARK 999
-	Phe 650	SEE REMARK 999
-	Pro 651	SEE REMARK 999
-	Cys 652	SEE REMARK 999
-	Asn 653	SEE REMARK 999
-	Arg 654	SEE REMARK 999
-	Val 655	SEE REMARK 999
-	Lys 656	SEE REMARK 999
-	Pro 657	SEE REMARK 999
-	Tyr 658	SEE REMARK 999
-	Val 659	SEE REMARK 999
-	His 660	SEE REMARK 999
Ser 133	-	expression tag
Gly 134	-	expression tag
Pro 135	-	expression tag
Ser 136	-	expression tag
Ser 137	-	expression tag
Gly 138	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	17289.9
All*	Total formula weight	17289.9

*Water molecules are not included.