2RMB
Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G, I... (A, C, E, G, I...) | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE | polymer | 165 | 18036.5 | 10 | UniProt (P62937) Pfam (PF00160) | HOMO SAPIENS | PPIASE, ROTAMASE, CYCLOPHILIN A |
| 2 | B, D, F, H, J... (B, D, F, H, J...) | CYCLOSPORIN A | polymer | 11 | 1234.7 | 10 | NOR (NOR00033) BIRD (PRD_000765) | TOLYPOCLADIUM INFLATUM | CICLOSPORIN, CICLOSPORINE |
| 3 | AA, BA, CA, DA, EA... (H, I, J, K, L...) | water | water | 18.0 | 676 | Chemie (HOH) |
Sequence modifications
B, D, F, H, J, L, N, P, R, T: 1 - 11 (NOR: NOR00033)
| PDB | External Database | Details |
|---|---|---|
| Dmt 5 | Bmt 5 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 20 |
| Total formula weight | 192711.6 | |
| All* | Total formula weight | 192711.6 |
