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2RMB

Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A

Functional Information from GO Data
ChainGOidnamespacecontents
A0000413biological_processprotein peptidyl-prolyl isomerization
A0001933biological_processnegative regulation of protein phosphorylation
A0001934biological_processpositive regulation of protein phosphorylation
A0003723molecular_functionRNA binding
A0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005925cellular_componentfocal adhesion
A0006457biological_processprotein folding
A0006469biological_processnegative regulation of protein kinase activity
A0006915biological_processapoptotic process
A0016018molecular_functioncyclosporin A binding
A0016020cellular_componentmembrane
A0016853molecular_functionisomerase activity
A0019076biological_processviral release from host cell
A0030168biological_processplatelet activation
A0030182biological_processneuron differentiation
A0030593biological_processneutrophil chemotaxis
A0030595biological_processleukocyte chemotaxis
A0031982cellular_componentvesicle
A0032148biological_processactivation of protein kinase B activity
A0032873biological_processnegative regulation of stress-activated MAPK cascade
A0032991cellular_componentprotein-containing complex
A0034389biological_processlipid droplet organization
A0034599biological_processcellular response to oxidative stress
A0034774cellular_componentsecretory granule lumen
A0042118biological_processendothelial cell activation
A0043410biological_processpositive regulation of MAPK cascade
A0045069biological_processregulation of viral genome replication
A0045070biological_processpositive regulation of viral genome replication
A0046790molecular_functionvirion binding
A0050714biological_processpositive regulation of protein secretion
A0051082molecular_functionunfolded protein binding
A0051092biological_processpositive regulation of NF-kappaB transcription factor activity
A0060352biological_processcell adhesion molecule production
A0061944biological_processnegative regulation of protein K48-linked ubiquitination
A0070062cellular_componentextracellular exosome
A0070527biological_processplatelet aggregation
A1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A1903901biological_processnegative regulation of viral life cycle
A1904399molecular_functionheparan sulfate binding
A1904813cellular_componentficolin-1-rich granule lumen
A2001233biological_processregulation of apoptotic signaling pathway
C0000413biological_processprotein peptidyl-prolyl isomerization
C0001933biological_processnegative regulation of protein phosphorylation
C0001934biological_processpositive regulation of protein phosphorylation
C0003723molecular_functionRNA binding
C0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
C0005178molecular_functionintegrin binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005925cellular_componentfocal adhesion
C0006457biological_processprotein folding
C0006469biological_processnegative regulation of protein kinase activity
C0006915biological_processapoptotic process
C0016018molecular_functioncyclosporin A binding
C0016020cellular_componentmembrane
C0016853molecular_functionisomerase activity
C0019076biological_processviral release from host cell
C0030168biological_processplatelet activation
C0030182biological_processneuron differentiation
C0030593biological_processneutrophil chemotaxis
C0030595biological_processleukocyte chemotaxis
C0031982cellular_componentvesicle
C0032148biological_processactivation of protein kinase B activity
C0032873biological_processnegative regulation of stress-activated MAPK cascade
C0032991cellular_componentprotein-containing complex
C0034389biological_processlipid droplet organization
C0034599biological_processcellular response to oxidative stress
C0034774cellular_componentsecretory granule lumen
C0042118biological_processendothelial cell activation
C0043410biological_processpositive regulation of MAPK cascade
C0045069biological_processregulation of viral genome replication
C0045070biological_processpositive regulation of viral genome replication
C0046790molecular_functionvirion binding
C0050714biological_processpositive regulation of protein secretion
C0051082molecular_functionunfolded protein binding
C0051092biological_processpositive regulation of NF-kappaB transcription factor activity
C0060352biological_processcell adhesion molecule production
C0061944biological_processnegative regulation of protein K48-linked ubiquitination
C0070062cellular_componentextracellular exosome
C0070527biological_processplatelet aggregation
C1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
C1903901biological_processnegative regulation of viral life cycle
C1904399molecular_functionheparan sulfate binding
C1904813cellular_componentficolin-1-rich granule lumen
C2001233biological_processregulation of apoptotic signaling pathway
E0000413biological_processprotein peptidyl-prolyl isomerization
E0001933biological_processnegative regulation of protein phosphorylation
E0001934biological_processpositive regulation of protein phosphorylation
E0003723molecular_functionRNA binding
E0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
E0005178molecular_functionintegrin binding
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005925cellular_componentfocal adhesion
E0006457biological_processprotein folding
E0006469biological_processnegative regulation of protein kinase activity
E0006915biological_processapoptotic process
E0016018molecular_functioncyclosporin A binding
E0016020cellular_componentmembrane
E0016853molecular_functionisomerase activity
E0019076biological_processviral release from host cell
E0030168biological_processplatelet activation
E0030182biological_processneuron differentiation
E0030593biological_processneutrophil chemotaxis
E0030595biological_processleukocyte chemotaxis
E0031982cellular_componentvesicle
E0032148biological_processactivation of protein kinase B activity
E0032873biological_processnegative regulation of stress-activated MAPK cascade
E0032991cellular_componentprotein-containing complex
E0034389biological_processlipid droplet organization
E0034599biological_processcellular response to oxidative stress
E0034774cellular_componentsecretory granule lumen
E0042118biological_processendothelial cell activation
E0043410biological_processpositive regulation of MAPK cascade
E0045069biological_processregulation of viral genome replication
E0045070biological_processpositive regulation of viral genome replication
E0046790molecular_functionvirion binding
E0050714biological_processpositive regulation of protein secretion
E0051082molecular_functionunfolded protein binding
E0051092biological_processpositive regulation of NF-kappaB transcription factor activity
E0060352biological_processcell adhesion molecule production
E0061944biological_processnegative regulation of protein K48-linked ubiquitination
E0070062cellular_componentextracellular exosome
E0070527biological_processplatelet aggregation
E1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
E1903901biological_processnegative regulation of viral life cycle
E1904399molecular_functionheparan sulfate binding
E1904813cellular_componentficolin-1-rich granule lumen
E2001233biological_processregulation of apoptotic signaling pathway
G0000413biological_processprotein peptidyl-prolyl isomerization
G0001933biological_processnegative regulation of protein phosphorylation
G0001934biological_processpositive regulation of protein phosphorylation
G0003723molecular_functionRNA binding
G0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
G0005178molecular_functionintegrin binding
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005925cellular_componentfocal adhesion
G0006457biological_processprotein folding
G0006469biological_processnegative regulation of protein kinase activity
G0006915biological_processapoptotic process
G0016018molecular_functioncyclosporin A binding
G0016020cellular_componentmembrane
G0016853molecular_functionisomerase activity
G0019076biological_processviral release from host cell
G0030168biological_processplatelet activation
G0030182biological_processneuron differentiation
G0030593biological_processneutrophil chemotaxis
G0030595biological_processleukocyte chemotaxis
G0031982cellular_componentvesicle
G0032148biological_processactivation of protein kinase B activity
G0032873biological_processnegative regulation of stress-activated MAPK cascade
G0032991cellular_componentprotein-containing complex
G0034389biological_processlipid droplet organization
G0034599biological_processcellular response to oxidative stress
G0034774cellular_componentsecretory granule lumen
G0042118biological_processendothelial cell activation
G0043410biological_processpositive regulation of MAPK cascade
G0045069biological_processregulation of viral genome replication
G0045070biological_processpositive regulation of viral genome replication
G0046790molecular_functionvirion binding
G0050714biological_processpositive regulation of protein secretion
G0051082molecular_functionunfolded protein binding
G0051092biological_processpositive regulation of NF-kappaB transcription factor activity
G0060352biological_processcell adhesion molecule production
G0061944biological_processnegative regulation of protein K48-linked ubiquitination
G0070062cellular_componentextracellular exosome
G0070527biological_processplatelet aggregation
G1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
G1903901biological_processnegative regulation of viral life cycle
G1904399molecular_functionheparan sulfate binding
G1904813cellular_componentficolin-1-rich granule lumen
G2001233biological_processregulation of apoptotic signaling pathway
I0000413biological_processprotein peptidyl-prolyl isomerization
I0001933biological_processnegative regulation of protein phosphorylation
I0001934biological_processpositive regulation of protein phosphorylation
I0003723molecular_functionRNA binding
I0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
I0005178molecular_functionintegrin binding
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005615cellular_componentextracellular space
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0005925cellular_componentfocal adhesion
I0006457biological_processprotein folding
I0006469biological_processnegative regulation of protein kinase activity
I0006915biological_processapoptotic process
I0016018molecular_functioncyclosporin A binding
I0016020cellular_componentmembrane
I0016853molecular_functionisomerase activity
I0019076biological_processviral release from host cell
I0030168biological_processplatelet activation
I0030182biological_processneuron differentiation
I0030593biological_processneutrophil chemotaxis
I0030595biological_processleukocyte chemotaxis
I0031982cellular_componentvesicle
I0032148biological_processactivation of protein kinase B activity
I0032873biological_processnegative regulation of stress-activated MAPK cascade
I0032991cellular_componentprotein-containing complex
I0034389biological_processlipid droplet organization
I0034599biological_processcellular response to oxidative stress
I0034774cellular_componentsecretory granule lumen
I0042118biological_processendothelial cell activation
I0043410biological_processpositive regulation of MAPK cascade
I0045069biological_processregulation of viral genome replication
I0045070biological_processpositive regulation of viral genome replication
I0046790molecular_functionvirion binding
I0050714biological_processpositive regulation of protein secretion
I0051082molecular_functionunfolded protein binding
I0051092biological_processpositive regulation of NF-kappaB transcription factor activity
I0060352biological_processcell adhesion molecule production
I0061944biological_processnegative regulation of protein K48-linked ubiquitination
I0070062cellular_componentextracellular exosome
I0070527biological_processplatelet aggregation
I1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
I1903901biological_processnegative regulation of viral life cycle
I1904399molecular_functionheparan sulfate binding
I1904813cellular_componentficolin-1-rich granule lumen
I2001233biological_processregulation of apoptotic signaling pathway
K0000413biological_processprotein peptidyl-prolyl isomerization
K0001933biological_processnegative regulation of protein phosphorylation
K0001934biological_processpositive regulation of protein phosphorylation
K0003723molecular_functionRNA binding
K0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
K0005178molecular_functionintegrin binding
K0005515molecular_functionprotein binding
K0005576cellular_componentextracellular region
K0005615cellular_componentextracellular space
K0005634cellular_componentnucleus
K0005737cellular_componentcytoplasm
K0005829cellular_componentcytosol
K0005925cellular_componentfocal adhesion
K0006457biological_processprotein folding
K0006469biological_processnegative regulation of protein kinase activity
K0006915biological_processapoptotic process
K0016018molecular_functioncyclosporin A binding
K0016020cellular_componentmembrane
K0016853molecular_functionisomerase activity
K0019076biological_processviral release from host cell
K0030168biological_processplatelet activation
K0030182biological_processneuron differentiation
K0030593biological_processneutrophil chemotaxis
K0030595biological_processleukocyte chemotaxis
K0031982cellular_componentvesicle
K0032148biological_processactivation of protein kinase B activity
K0032873biological_processnegative regulation of stress-activated MAPK cascade
K0032991cellular_componentprotein-containing complex
K0034389biological_processlipid droplet organization
K0034599biological_processcellular response to oxidative stress
K0034774cellular_componentsecretory granule lumen
K0042118biological_processendothelial cell activation
K0043410biological_processpositive regulation of MAPK cascade
K0045069biological_processregulation of viral genome replication
K0045070biological_processpositive regulation of viral genome replication
K0046790molecular_functionvirion binding
K0050714biological_processpositive regulation of protein secretion
K0051082molecular_functionunfolded protein binding
K0051092biological_processpositive regulation of NF-kappaB transcription factor activity
K0060352biological_processcell adhesion molecule production
K0061944biological_processnegative regulation of protein K48-linked ubiquitination
K0070062cellular_componentextracellular exosome
K0070527biological_processplatelet aggregation
K1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
K1903901biological_processnegative regulation of viral life cycle
K1904399molecular_functionheparan sulfate binding
K1904813cellular_componentficolin-1-rich granule lumen
K2001233biological_processregulation of apoptotic signaling pathway
M0000413biological_processprotein peptidyl-prolyl isomerization
M0001933biological_processnegative regulation of protein phosphorylation
M0001934biological_processpositive regulation of protein phosphorylation
M0003723molecular_functionRNA binding
M0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
M0005178molecular_functionintegrin binding
M0005515molecular_functionprotein binding
M0005576cellular_componentextracellular region
M0005615cellular_componentextracellular space
M0005634cellular_componentnucleus
M0005737cellular_componentcytoplasm
M0005829cellular_componentcytosol
M0005925cellular_componentfocal adhesion
M0006457biological_processprotein folding
M0006469biological_processnegative regulation of protein kinase activity
M0006915biological_processapoptotic process
M0016018molecular_functioncyclosporin A binding
M0016020cellular_componentmembrane
M0016853molecular_functionisomerase activity
M0019076biological_processviral release from host cell
M0030168biological_processplatelet activation
M0030182biological_processneuron differentiation
M0030593biological_processneutrophil chemotaxis
M0030595biological_processleukocyte chemotaxis
M0031982cellular_componentvesicle
M0032148biological_processactivation of protein kinase B activity
M0032873biological_processnegative regulation of stress-activated MAPK cascade
M0032991cellular_componentprotein-containing complex
M0034389biological_processlipid droplet organization
M0034599biological_processcellular response to oxidative stress
M0034774cellular_componentsecretory granule lumen
M0042118biological_processendothelial cell activation
M0043410biological_processpositive regulation of MAPK cascade
M0045069biological_processregulation of viral genome replication
M0045070biological_processpositive regulation of viral genome replication
M0046790molecular_functionvirion binding
M0050714biological_processpositive regulation of protein secretion
M0051082molecular_functionunfolded protein binding
M0051092biological_processpositive regulation of NF-kappaB transcription factor activity
M0060352biological_processcell adhesion molecule production
M0061944biological_processnegative regulation of protein K48-linked ubiquitination
M0070062cellular_componentextracellular exosome
M0070527biological_processplatelet aggregation
M1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
M1903901biological_processnegative regulation of viral life cycle
M1904399molecular_functionheparan sulfate binding
M1904813cellular_componentficolin-1-rich granule lumen
M2001233biological_processregulation of apoptotic signaling pathway
O0000413biological_processprotein peptidyl-prolyl isomerization
O0001933biological_processnegative regulation of protein phosphorylation
O0001934biological_processpositive regulation of protein phosphorylation
O0003723molecular_functionRNA binding
O0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
O0005178molecular_functionintegrin binding
O0005515molecular_functionprotein binding
O0005576cellular_componentextracellular region
O0005615cellular_componentextracellular space
O0005634cellular_componentnucleus
O0005737cellular_componentcytoplasm
O0005829cellular_componentcytosol
O0005925cellular_componentfocal adhesion
O0006457biological_processprotein folding
O0006469biological_processnegative regulation of protein kinase activity
O0006915biological_processapoptotic process
O0016018molecular_functioncyclosporin A binding
O0016020cellular_componentmembrane
O0016853molecular_functionisomerase activity
O0019076biological_processviral release from host cell
O0030168biological_processplatelet activation
O0030182biological_processneuron differentiation
O0030593biological_processneutrophil chemotaxis
O0030595biological_processleukocyte chemotaxis
O0031982cellular_componentvesicle
O0032148biological_processactivation of protein kinase B activity
O0032873biological_processnegative regulation of stress-activated MAPK cascade
O0032991cellular_componentprotein-containing complex
O0034389biological_processlipid droplet organization
O0034599biological_processcellular response to oxidative stress
O0034774cellular_componentsecretory granule lumen
O0042118biological_processendothelial cell activation
O0043410biological_processpositive regulation of MAPK cascade
O0045069biological_processregulation of viral genome replication
O0045070biological_processpositive regulation of viral genome replication
O0046790molecular_functionvirion binding
O0050714biological_processpositive regulation of protein secretion
O0051082molecular_functionunfolded protein binding
O0051092biological_processpositive regulation of NF-kappaB transcription factor activity
O0060352biological_processcell adhesion molecule production
O0061944biological_processnegative regulation of protein K48-linked ubiquitination
O0070062cellular_componentextracellular exosome
O0070527biological_processplatelet aggregation
O1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
O1903901biological_processnegative regulation of viral life cycle
O1904399molecular_functionheparan sulfate binding
O1904813cellular_componentficolin-1-rich granule lumen
O2001233biological_processregulation of apoptotic signaling pathway
Q0000413biological_processprotein peptidyl-prolyl isomerization
Q0001933biological_processnegative regulation of protein phosphorylation
Q0001934biological_processpositive regulation of protein phosphorylation
Q0003723molecular_functionRNA binding
Q0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
Q0005178molecular_functionintegrin binding
Q0005515molecular_functionprotein binding
Q0005576cellular_componentextracellular region
Q0005615cellular_componentextracellular space
Q0005634cellular_componentnucleus
Q0005737cellular_componentcytoplasm
Q0005829cellular_componentcytosol
Q0005925cellular_componentfocal adhesion
Q0006457biological_processprotein folding
Q0006469biological_processnegative regulation of protein kinase activity
Q0006915biological_processapoptotic process
Q0016018molecular_functioncyclosporin A binding
Q0016020cellular_componentmembrane
Q0016853molecular_functionisomerase activity
Q0019076biological_processviral release from host cell
Q0030168biological_processplatelet activation
Q0030182biological_processneuron differentiation
Q0030593biological_processneutrophil chemotaxis
Q0030595biological_processleukocyte chemotaxis
Q0031982cellular_componentvesicle
Q0032148biological_processactivation of protein kinase B activity
Q0032873biological_processnegative regulation of stress-activated MAPK cascade
Q0032991cellular_componentprotein-containing complex
Q0034389biological_processlipid droplet organization
Q0034599biological_processcellular response to oxidative stress
Q0034774cellular_componentsecretory granule lumen
Q0042118biological_processendothelial cell activation
Q0043410biological_processpositive regulation of MAPK cascade
Q0045069biological_processregulation of viral genome replication
Q0045070biological_processpositive regulation of viral genome replication
Q0046790molecular_functionvirion binding
Q0050714biological_processpositive regulation of protein secretion
Q0051082molecular_functionunfolded protein binding
Q0051092biological_processpositive regulation of NF-kappaB transcription factor activity
Q0060352biological_processcell adhesion molecule production
Q0061944biological_processnegative regulation of protein K48-linked ubiquitination
Q0070062cellular_componentextracellular exosome
Q0070527biological_processplatelet aggregation
Q1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Q1903901biological_processnegative regulation of viral life cycle
Q1904399molecular_functionheparan sulfate binding
Q1904813cellular_componentficolin-1-rich granule lumen
Q2001233biological_processregulation of apoptotic signaling pathway
S0000413biological_processprotein peptidyl-prolyl isomerization
S0001933biological_processnegative regulation of protein phosphorylation
S0001934biological_processpositive regulation of protein phosphorylation
S0003723molecular_functionRNA binding
S0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
S0005178molecular_functionintegrin binding
S0005515molecular_functionprotein binding
S0005576cellular_componentextracellular region
S0005615cellular_componentextracellular space
S0005634cellular_componentnucleus
S0005737cellular_componentcytoplasm
S0005829cellular_componentcytosol
S0005925cellular_componentfocal adhesion
S0006457biological_processprotein folding
S0006469biological_processnegative regulation of protein kinase activity
S0006915biological_processapoptotic process
S0016018molecular_functioncyclosporin A binding
S0016020cellular_componentmembrane
S0016853molecular_functionisomerase activity
S0019076biological_processviral release from host cell
S0030168biological_processplatelet activation
S0030182biological_processneuron differentiation
S0030593biological_processneutrophil chemotaxis
S0030595biological_processleukocyte chemotaxis
S0031982cellular_componentvesicle
S0032148biological_processactivation of protein kinase B activity
S0032873biological_processnegative regulation of stress-activated MAPK cascade
S0032991cellular_componentprotein-containing complex
S0034389biological_processlipid droplet organization
S0034599biological_processcellular response to oxidative stress
S0034774cellular_componentsecretory granule lumen
S0042118biological_processendothelial cell activation
S0043410biological_processpositive regulation of MAPK cascade
S0045069biological_processregulation of viral genome replication
S0045070biological_processpositive regulation of viral genome replication
S0046790molecular_functionvirion binding
S0050714biological_processpositive regulation of protein secretion
S0051082molecular_functionunfolded protein binding
S0051092biological_processpositive regulation of NF-kappaB transcription factor activity
S0060352biological_processcell adhesion molecule production
S0061944biological_processnegative regulation of protein K48-linked ubiquitination
S0070062cellular_componentextracellular exosome
S0070527biological_processplatelet aggregation
S1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
S1903901biological_processnegative regulation of viral life cycle
S1904399molecular_functionheparan sulfate binding
S1904813cellular_componentficolin-1-rich granule lumen
S2001233biological_processregulation of apoptotic signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues24
DetailsBINDING SITE FOR CHAIN B OF CYCLOSPORIN A
ChainResidue
AARG55
ALEU122
AHIS126
AARG148
BHOH2002
BHOH2003
BHOH2004
IPRO30
ILYS31
ITYR79
KTHR73
APHE60
KGLU81
KALA103
LABA6
LSAR7
LMLE8
AGLN63
AGLY72
AASN102
AALA103
AGLN111
APHE113
ATRP121

site_idAC2
Number of Residues24
DetailsBINDING SITE FOR CHAIN D OF CYCLOSPORIN A
ChainResidue
ALYS31
ATYR79
CARG55
CPHE60
CGLN63
CGLY72
CASN102
CALA103
CGLN111
CPHE113
CTRP121
CLEU122
CHIS126
CARG148
CHOH2019
MTHR73
MGLU81
MLYS82
MALA103
MHOH2016
NDMT5
NABA6
NSAR7
NMLE8

site_idAC3
Number of Residues23
DetailsBINDING SITE FOR CHAIN F OF CYCLOSPORIN A
ChainResidue
CPRO30
CLYS31
CTYR79
EARG55
EPHE60
EGLN63
EGLY72
EASN102
EGLN111
EPHE113
ETRP121
ELEU122
EHIS126
EARG148
FHOH2001
FHOH2002
OTHR73
OGLU81
OALA103
PDMT5
PABA6
PSAR7
PMLE8

site_idAC4
Number of Residues23
DetailsBINDING SITE FOR CHAIN H OF CYCLOSPORIN A
ChainResidue
ELYS31
ETYR79
GARG55
GPHE60
GGLN63
GGLY72
GASN102
GALA103
GGLN111
GPHE113
GTRP121
GLEU122
GHIS126
GARG148
HHOH2001
HHOH2002
QTHR73
QGLU81
QLYS82
QALA103
RDMT5
RSAR7
RMLE8

site_idAC5
Number of Residues23
DetailsBINDING SITE FOR CHAIN J OF CYCLOSPORIN A
ChainResidue
IGLY72
IASN102
IALA103
IGLN111
IPHE113
ITRP121
IHIS126
IHOH2029
IHOH2063
JHOH2001
JHOH2002
STHR73
SGLU81
SALA103
TDMT5
TABA6
TSAR7
TMLE8
GLYS31
GTYR79
IARG55
IPHE60
IGLN63

site_idAC6
Number of Residues22
DetailsBINDING SITE FOR CHAIN L OF CYCLOSPORIN A
ChainResidue
ATHR73
AGLU81
AALA103
BABA6
BSAR7
BMLE8
KARG55
KPHE60
KGLN63
KGLY72
KASN102
KALA103
KGLN111
KPHE113
KTRP121
KLEU122
KHIS126
KHOH2026
LHOH2001
MPRO30
MLYS31
MTYR79

site_idAC7
Number of Residues19
DetailsBINDING SITE FOR CHAIN N OF CYCLOSPORIN A
ChainResidue
CTHR73
CGLU81
CLYS82
CALA103
DDMT5
DABA6
DSAR7
DMLE8
MARG55
MPHE60
MGLN63
MGLY72
MASN102
MALA103
MPHE113
MTRP121
MHIS126
OLYS31
OTYR79

site_idAC8
Number of Residues26
DetailsBINDING SITE FOR CHAIN P OF CYCLOSPORIN A
ChainResidue
ETHR73
EGLU81
EALA103
FDMT5
FABA6
FSAR7
FMLE8
OARG55
OPHE60
OGLN63
OGLY72
OALA101
OASN102
OALA103
OGLN111
OPHE113
OTRP121
OHIS126
OARG148
OHOH2059
PHOH2001
PHOH2002
PHOH2003
QMET1
QLYS31
QTYR79

site_idAC9
Number of Residues21
DetailsBINDING SITE FOR CHAIN R OF CYCLOSPORIN A
ChainResidue
GTHR73
GGLU81
GALA103
HDMT5
HABA6
HSAR7
QARG55
QPHE60
QGLN63
QGLY72
QASN102
QALA103
QGLN111
QPHE113
QTRP121
QLEU122
QHIS126
RHOH2001
RHOH2002
SLYS31
STYR79

site_idBC1
Number of Residues23
DetailsBINDING SITE FOR CHAIN T OF CYCLOSPORIN A
ChainResidue
ITHR73
IGLU81
IALA103
IHOH2034
JDMT5
JABA6
JSAR7
JMLE8
KLYS31
KTYR79
SARG55
SPHE60
SGLN63
SGLY72
SASN102
SALA103
SGLN111
SPHE113
STRP121
SLEU122
SHIS126
THOH2001
THOH2002

Functional Information from PROSITE/UniProt
site_idPS00170
Number of Residues18
DetailsCSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgScFHRIIpgFMcQGG
ChainResidueDetails
ATYR48-GLY65

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1560
DetailsDomain: {"description":"PPIase cyclophilin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00156","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues10
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues10
DetailsModified residue: {"description":"N-acetylvaline; partial; in Peptidyl-prolyl cis-trans isomerase A, N-terminally processed","evidences":[{"source":"PubMed","id":"25489052","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Claeys D."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues20
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues30
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues10
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues10
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues10
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"20364129","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25678563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues10
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P17742","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues10
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues10
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate"}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues20
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idMCSA1
Number of Residues7
DetailsM-CSA 189
ChainResidueDetails
AARG55electrostatic stabiliser, hydrogen bond donor, steric role
APHE60polar/non-polar interaction, steric role
AGLN63electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
AASN102electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
APHE113polar/non-polar interaction, steric role
ALEU122polar/non-polar interaction, steric role
AHIS126polar/non-polar interaction, steric role

site_idMCSA10
Number of Residues7
DetailsM-CSA 189
ChainResidueDetails
SARG55electrostatic stabiliser, hydrogen bond donor, steric role
SPHE60polar/non-polar interaction, steric role
SGLN63electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
SASN102electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
SPHE113polar/non-polar interaction, steric role
SLEU122polar/non-polar interaction, steric role
SHIS126polar/non-polar interaction, steric role

site_idMCSA2
Number of Residues7
DetailsM-CSA 189
ChainResidueDetails
CARG55electrostatic stabiliser, hydrogen bond donor, steric role
CPHE60polar/non-polar interaction, steric role
CGLN63electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
CASN102electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
CPHE113polar/non-polar interaction, steric role
CLEU122polar/non-polar interaction, steric role
CHIS126polar/non-polar interaction, steric role

site_idMCSA3
Number of Residues7
DetailsM-CSA 189
ChainResidueDetails
EARG55electrostatic stabiliser, hydrogen bond donor, steric role
EPHE60polar/non-polar interaction, steric role
EGLN63electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
EASN102electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
EPHE113polar/non-polar interaction, steric role
ELEU122polar/non-polar interaction, steric role
EHIS126polar/non-polar interaction, steric role

site_idMCSA4
Number of Residues7
DetailsM-CSA 189
ChainResidueDetails
GARG55electrostatic stabiliser, hydrogen bond donor, steric role
GPHE60polar/non-polar interaction, steric role
GGLN63electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
GASN102electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
GPHE113polar/non-polar interaction, steric role
GLEU122polar/non-polar interaction, steric role
GHIS126polar/non-polar interaction, steric role

site_idMCSA5
Number of Residues7
DetailsM-CSA 189
ChainResidueDetails
IARG55electrostatic stabiliser, hydrogen bond donor, steric role
IPHE60polar/non-polar interaction, steric role
IGLN63electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
IASN102electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
IPHE113polar/non-polar interaction, steric role
ILEU122polar/non-polar interaction, steric role
IHIS126polar/non-polar interaction, steric role

site_idMCSA6
Number of Residues7
DetailsM-CSA 189
ChainResidueDetails
KARG55electrostatic stabiliser, hydrogen bond donor, steric role
KPHE60polar/non-polar interaction, steric role
KGLN63electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
KASN102electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
KPHE113polar/non-polar interaction, steric role
KLEU122polar/non-polar interaction, steric role
KHIS126polar/non-polar interaction, steric role

site_idMCSA7
Number of Residues7
DetailsM-CSA 189
ChainResidueDetails
MARG55electrostatic stabiliser, hydrogen bond donor, steric role
MPHE60polar/non-polar interaction, steric role
MGLN63electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
MASN102electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
MPHE113polar/non-polar interaction, steric role
MLEU122polar/non-polar interaction, steric role
MHIS126polar/non-polar interaction, steric role

site_idMCSA8
Number of Residues7
DetailsM-CSA 189
ChainResidueDetails
OARG55electrostatic stabiliser, hydrogen bond donor, steric role
OPHE60polar/non-polar interaction, steric role
OGLN63electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
OASN102electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
OPHE113polar/non-polar interaction, steric role
OLEU122polar/non-polar interaction, steric role
OHIS126polar/non-polar interaction, steric role

site_idMCSA9
Number of Residues7
DetailsM-CSA 189
ChainResidueDetails
QARG55electrostatic stabiliser, hydrogen bond donor, steric role
QPHE60polar/non-polar interaction, steric role
QGLN63electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
QASN102electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
QPHE113polar/non-polar interaction, steric role
QLEU122polar/non-polar interaction, steric role
QHIS126polar/non-polar interaction, steric role

238582

PDB entries from 2025-07-09

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