2RKU
Structure of PLK1 in complex with BI2536
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase PLK1 | polymer | 294 | 33823.5 | 1 | UniProt (P53350) Pfam (PF00069) | Homo sapiens (human) | Polo-like kinase 1, PLK-1, Serine/threonine-protein kinase 13, STPK13 |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide | non-polymer | 521.7 | 1 | Chemie (R78) | |||
| 4 | D, E (A) | L(+)-TARTARIC ACID | non-polymer | 150.1 | 2 | Chemie (TLA) | |||
| 5 | F, G (A) | S,R MESO-TARTARIC ACID | non-polymer | 150.1 | 2 | Chemie (SRT) | |||
| 6 | H (A) | D(-)-TARTARIC ACID | non-polymer | 150.1 | 1 | Chemie (TAR) | |||
| 7 | I (A) | water | water | 18.0 | 285 | Chemie (HOH) |
Sequence modifications
A: 37 - 330 (UniProt: P53350)
| PDB | External Database | Details |
|---|---|---|
| Val 210 | Thr 210 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33823.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1337.5 | |
| All* | Total formula weight | 35161.0 |
