2RIW

The Reactive loop cleaved human Thyroxine Binding Globulin complexed with thyroxine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Thyroxine-binding globulin	polymer	338	37887.5	1	UniProt (P05543) Pfam (PF00079) In PDB	Homo sapiens (human)	TBG, T4-binding globulin, Serpin A7
2	B	Thyroxine-binding globulin	polymer	40	4605.4	1	UniProt (P05543) In PDB	Homo sapiens (human)	TBG, T4-binding globulin, Serpin A7
3	A	3,5,3',5'-TETRAIODO-L-THYRONINE	non-polymer		776.9	1	Chemie (T44)
4		water	water		18.0	295	Chemie (HOH)

Sequence modifications

A: 19 - 355 (UniProt: P05543)

PDB	External Database	Details
Ser 18	-	expression tag
Gly 346	Ala 366	SEE REMARK 999
Ala 347	Val 367	SEE REMARK 999
Met 348	Pro 368	SEE REMARK 999
Phe 349	Glu 369	SEE REMARK 999
Leu 350	Val 370	SEE REMARK 999
Glu 351	Glu 371	SEE REMARK 999
Ala 352	Leu 372	SEE REMARK 999
Ile 353	Ser 373	SEE REMARK 999
Pro 354	Asp 374	SEE REMARK 999
Arg 355	Gln 375	SEE REMARK 999

B: 356 - 395 (UniProt: P05543)

PDB	External Database	Details
Ser 356	Pro 376	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	42492.9
Non-Polymers*	Number of molecules	1
	Total formula weight	776.9
All*	Total formula weight	43269.8

*Water molecules are not included.