2RIO

Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation of non-conventional splicing

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Serine/threonine-protein kinase/endoribonuclease IRE1	polymer	434	50038.4	2	UniProt (P32361) Pfam (PF00069) Pfam (PF06479)	Saccharomyces cerevisiae (baker's yeast)	Endoplasmic reticulum-to-nucleus signaling 1, Serine/threonine-protein kinase, Endoribonuclease
2	C, F (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
3	D, G (A, B)	STRONTIUM ION	non-polymer		87.6	2	Chemie (SR)
4	E, H (A, B)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	2	Chemie (ADP)

Sequence modifications

A, B: 1 - 211 (UniProt: P32361)
A, B: 212 - 434 (UniProt: P32361)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	100076.8
Non-Polymers*	Number of molecules	6
	Total formula weight	1078.3
All*	Total formula weight	101155.0

*Water molecules are not included.