2RD8
Human Thymidylate Synthase Stabilized in Active Conformation by R163K Mutation: Asymmetry and Reactivity of Cys195
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Thymidylate synthase | polymer | 313 | 35734.9 | 1 | UniProt (P04818) Pfam (PF00303) | Homo sapiens (human) | TS, TSase |
| 2 | B (B) | Thymidylate synthase | polymer | 313 | 35811.0 | 1 | UniProt (P04818) Pfam (PF00303) | Homo sapiens (human) | |
| 3 | C (A) | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 1 | Chemie (BME) | |||
| 4 | D, E (B) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 88 | Chemie (HOH) |
Sequence modifications
A: 1 - 313 (UniProt: P04818)
B: 1 - 313 (UniProt: P04818)
| PDB | External Database | Details |
|---|---|---|
| Lys 163 | Arg 163 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Lys 163 | Arg 163 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71546.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 268.1 | |
| All* | Total formula weight | 71814.0 |
