2RAH
Human FDPS synthase in complex with novel inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Farnesyl pyrophosphate synthetase | polymer | 378 | 43471.4 | 1 | UniProt (P14324) Pfam (PF00348) In PDB | Homo sapiens (human) | FPP synthetase, FPS, Farnesyl diphosphate synthetase |
2 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
3 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
4 | A | [(7R)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl(hydroxy)methylene]bis(phosphonic acid) | non-polymer | 309.1 | 1 | Chemie (11P) | |||
5 | water | water | 18.0 | 113 | Chemie (HOH) |
Sequence modifications
A: 1 - 353 (UniProt: P14324)
PDB | External Database | Details |
---|---|---|
Met -24 | - | expression tag |
Gly -23 | - | expression tag |
Ser -22 | - | expression tag |
Ser -21 | - | expression tag |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
Ser -14 | - | expression tag |
Ser -13 | - | expression tag |
Gly -12 | - | expression tag |
Arg -11 | - | expression tag |
Glu -10 | - | expression tag |
Asn -9 | - | expression tag |
Leu -8 | - | expression tag |
Tyr -7 | - | expression tag |
Phe -6 | - | expression tag |
Gln -5 | - | expression tag |
Gly -4 | - | expression tag |
His -3 | - | expression tag |
Met -2 | - | expression tag |
Gly -1 | - | expression tag |
His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 43471.4 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 429.5 | |
All* | Total formula weight | 43900.9 |