2RAH

Human FDPS synthase in complex with novel inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004659	molecular_function	prenyltransferase activity
A	0008299	biological_process	isoprenoid biosynthetic process
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups

Functional Information from PROSITE/UniProt

site_id	PS00444
Number of Residues	13
Details	POLYPRENYL_SYNTHASE_2 Polyprenyl synthases signature 2. MGefFQIqDDYlD

Chain	Residue	Details
A	MET235-ASP247

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site_id	PS00723
Number of Residues	15
Details	POLYPRENYL_SYNTHASE_1 Polyprenyl synthases signature 1. LVaDDim..DssltRRG

Chain	Residue	Details
A	LEU100-GLY114

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:16684881, ECO:0007744|PDB:1ZW5

Chain	Residue	Details
A	GLY123
A	LEU126
A	GLN162
A	ILE169
A	LEU173
A	PRO179

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site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING:

Chain	Residue	Details
A	ALA178
A	LYS266
A	CYS267
A	GLU306
A	SER323

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	TYR332

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site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Important for determining product chain length => ECO:0000250

Chain	Residue	Details
A	SER164
A	TYR165

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	GLY123

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS353

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1fps

Chain	Residue	Details
A	ARG112
A	PHE239

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