2R4H

Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1	polymer	112	12829.5	3	UniProt (Q96QZ7) Pfam (PF00595) In PDB	Homo sapiens (human)	BAI1-associated protein 1, BAP-1, Membrane-associated guanylate kinase inverted 1, MAGI-1, Atrophin-1-interacting protein 3, AIP3, WW domain-containing protein 3, WWP3, Trinucleotide repeat-containing gene 19 protein
2	A, C	HISTIDINE	non-polymer		156.2	5	Chemie (HIS)
3		water	water		18.0	114	Chemie (HOH)

Sequence modifications

A, B, C: 2 - 86 (UniProt: Q96QZ7)

PDB	External Database	Details
Met -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Leu -9	-	expression tag
Gly -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag
Met 1	-	expression tag
Ser 43	Cys 1190	engineered mutation
Glu 87	-	expression tag
Thr 88	-	expression tag
Ser 89	-	expression tag
Val 90	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	38488.6
Non-Polymers*	Number of molecules	5
	Total formula weight	780.8
All*	Total formula weight	39269.4

*Water molecules are not included.