2R09
Crystal Structure of Autoinhibited Form of Grp1 Arf GTPase Exchange Factor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cytohesin-3 | polymer | 347 | 40838.0 | 2 | UniProt (O08967) Pfam (PF01369) Pfam (PF00169) | Mus musculus (house mouse) | PH, SEC7 and coiled-coil domain-containing protein 3, CLM3, SEC7 homolog C, mSec7-3, ARF nucleotide-binding site opener 3, Protein ARNO3, General receptor of phosphoinositides 1, Grp1 |
| 2 | C, D, E, F, G... (A, B) | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 3 | I, M (A, B) | INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE | non-polymer | 500.1 | 2 | Chemie (4IP) | |||
| 4 | J (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 5 | K (A) | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL | non-polymer | 398.5 | 1 | Chemie (PE5) | |||
| 6 | N, O (A, B) | water | water | 18.0 | 807 | Chemie (HOH) |
Sequence modifications
A, B: 63 - 399 (UniProt: O08967)
| PDB | External Database | Details |
|---|---|---|
| Mse 53 | - | expression tag |
| Gly 54 | - | expression tag |
| His 55 | - | expression tag |
| His 56 | - | expression tag |
| His 57 | - | expression tag |
| His 58 | - | expression tag |
| His 59 | - | expression tag |
| His 60 | - | expression tag |
| Gly 61 | - | expression tag |
| Ser 62 | - | expression tag |
| Ala 68 | Lys 68 | engineered mutation |
| Tyr 260 | His 260 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 81676.0 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2221.3 | |
| All* | Total formula weight | 83897.3 |
