2QQH
Structure of C8a-MACPF reveals mechanism of membrane attack in complement immune defense
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Complement component C8 alpha chain | polymer | 334 | 37543.2 | 1 | UniProt (P07357) Pfam (PF01823) | Homo sapiens (human) | Complement component 8 subunit alpha |
| 2 | B, C, D (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 3 | E (A) | NICKEL (II) ION | non-polymer | 58.7 | 1 | Chemie (NI) | |||
| 4 | F (A) | water | water | 18.0 | 44 | Chemie (HOH) |
Sequence modifications
A: 103 - 336 (UniProt: P07357)
| PDB | External Database | Details |
|---|---|---|
| Gly 101 | - | expression tag |
| Ser 102 | - | expression tag |
| Ser 164 | Cys 194 | engineered mutation |
| Ala 463 | - | expression tag |
| Ala 464 | - | expression tag |
| Ala 465 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37543.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 346.9 | |
| All* | Total formula weight | 37890.1 |
