2QQH
Structure of C8a-MACPF reveals mechanism of membrane attack in complement immune defense
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1 |
| Chain | Residue |
| A | GLY118 |
| A | SER119 |
| A | GLN120 |
| A | LYS121 |
| A | HOH515 |
| A | HOH531 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 A 466 |
| Chain | Residue |
| A | ARG394 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 467 |
| Chain | Residue |
| A | HIS440 |
| A | HOH542 |
| A | LYS275 |
| A | ARG439 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NI A 500 |
| Chain | Residue |
| A | HIS186 |
| A | GLU188 |
| A | HIS270 |
| A | HOH524 |
| A | HOH529 |
Functional Information from PROSITE/UniProt
| site_id | PS00279 |
| Number of Residues | 12 |
| Details | MACPF_1 Membrane attack complex/perforin (MACPF) domain signature. YakfindYGTHY |
| Chain | Residue | Details |
| A | TYR300-TYR311 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 15 |
| Details | Transmembrane: {"description":"Beta stranded","evidences":[{"source":"PubMed","id":"30552328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6H04","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30552328","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
