2QIS
Crystal structure of human farnesyl pyrophosphate synthase T210S mutant bound to risedronate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Farnesyl pyrophosphate synthetase | polymer | 374 | 42999.8 | 1 | UniProt (P14324) Pfam (PF00348) | Homo sapiens (human) | FPP synthetase, FPS, Farnesyl diphosphate synthetase [Includes: Dimethylallyltranstransferase (EC 2.5.1.1); Geranyltranstransferase (EC 2.5.1.10)] |
| 2 | B, C, D (A) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 3 | E (A) | 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID | non-polymer | 283.1 | 1 | Chemie (RIS) | |||
| 4 | F (A) | water | water | 18.0 | 173 | Chemie (HOH) |
Sequence modifications
A: 15 - 367 (UniProt: P14324)
| PDB | External Database | Details |
|---|---|---|
| Gly -6 | - | cloning artifact |
| Ser -5 | - | cloning artifact |
| Ser -4 | - | cloning artifact |
| His -3 | - | cloning artifact |
| His -2 | - | cloning artifact |
| His -1 | - | cloning artifact |
| His 0 | - | cloning artifact |
| His 1 | - | cloning artifact |
| His 2 | - | cloning artifact |
| Ser 3 | - | cloning artifact |
| Ser 4 | - | cloning artifact |
| Gly 5 | - | cloning artifact |
| Arg 6 | - | cloning artifact |
| Glu 7 | - | cloning artifact |
| Asn 8 | - | cloning artifact |
| Leu 9 | - | cloning artifact |
| Tyr 10 | - | cloning artifact |
| Phe 11 | - | cloning artifact |
| Gln 12 | - | cloning artifact |
| Gly 13 | - | cloning artifact |
| His 14 | - | cloning artifact |
| Ser 215 | Thr 201 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42999.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 356.0 | |
| All* | Total formula weight | 43355.8 |
