2QFV

Crystal structure of Saccharomyces cerevesiae mitochondrial NADP(+)-dependent isocitrate dehydrogenase in complex with NADP(+)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Isocitrate dehydrogenase [NADP]	polymer	427	48143.1	4	UniProt (P21954) Pfam (PF00180)	Saccharomyces cerevisiae (yeast)	Idp1p, Oxalosuccinate decarboxylase, IDH, NADP+, -specific ICDH, IDP
2	E, F, G, H (A, B, C, D)	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	4	Chemie (NAP)
3	I, J, K, L (A, B, C, D)	water	water		18.0	950	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 413 (UniProt: P21954)

PDB	External Database	Details
Met -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
Ala -6	-	expression tag
Met -5	-	expression tag
Gly -4	-	expression tag
Ile -3	-	expression tag
Pro -2	-	expression tag
Gly -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	192572.3
Non-Polymers*	Number of molecules	4
	Total formula weight	2973.6
All*	Total formula weight	195546.0

*Water molecules are not included.