2QFV
Crystal structure of Saccharomyces cerevesiae mitochondrial NADP(+)-dependent isocitrate dehydrogenase in complex with NADP(+)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0004450 | molecular_function | isocitrate dehydrogenase (NADP+) activity |
A | 0005515 | molecular_function | protein binding |
A | 0005739 | cellular_component | mitochondrion |
A | 0006097 | biological_process | glyoxylate cycle |
A | 0006099 | biological_process | tricarboxylic acid cycle |
A | 0006102 | biological_process | isocitrate metabolic process |
A | 0006537 | biological_process | glutamate biosynthetic process |
A | 0006739 | biological_process | NADP metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0042645 | cellular_component | mitochondrial nucleoid |
A | 0046872 | molecular_function | metal ion binding |
A | 0051287 | molecular_function | NAD binding |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0004450 | molecular_function | isocitrate dehydrogenase (NADP+) activity |
B | 0005515 | molecular_function | protein binding |
B | 0005739 | cellular_component | mitochondrion |
B | 0006097 | biological_process | glyoxylate cycle |
B | 0006099 | biological_process | tricarboxylic acid cycle |
B | 0006102 | biological_process | isocitrate metabolic process |
B | 0006537 | biological_process | glutamate biosynthetic process |
B | 0006739 | biological_process | NADP metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0042645 | cellular_component | mitochondrial nucleoid |
B | 0046872 | molecular_function | metal ion binding |
B | 0051287 | molecular_function | NAD binding |
C | 0000287 | molecular_function | magnesium ion binding |
C | 0004450 | molecular_function | isocitrate dehydrogenase (NADP+) activity |
C | 0005515 | molecular_function | protein binding |
C | 0005739 | cellular_component | mitochondrion |
C | 0006097 | biological_process | glyoxylate cycle |
C | 0006099 | biological_process | tricarboxylic acid cycle |
C | 0006102 | biological_process | isocitrate metabolic process |
C | 0006537 | biological_process | glutamate biosynthetic process |
C | 0006739 | biological_process | NADP metabolic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
C | 0042645 | cellular_component | mitochondrial nucleoid |
C | 0046872 | molecular_function | metal ion binding |
C | 0051287 | molecular_function | NAD binding |
D | 0000287 | molecular_function | magnesium ion binding |
D | 0004450 | molecular_function | isocitrate dehydrogenase (NADP+) activity |
D | 0005515 | molecular_function | protein binding |
D | 0005739 | cellular_component | mitochondrion |
D | 0006097 | biological_process | glyoxylate cycle |
D | 0006099 | biological_process | tricarboxylic acid cycle |
D | 0006102 | biological_process | isocitrate metabolic process |
D | 0006537 | biological_process | glutamate biosynthetic process |
D | 0006739 | biological_process | NADP metabolic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
D | 0042645 | cellular_component | mitochondrial nucleoid |
D | 0046872 | molecular_function | metal ion binding |
D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE NAP A 1001 |
Chain | Residue |
A | LYS73 |
A | GLY312 |
A | THR313 |
A | THR315 |
A | ARG316 |
A | HIS317 |
A | ASN330 |
A | HOH1007 |
A | HOH1061 |
A | HOH1075 |
A | HOH1145 |
A | ALA75 |
A | HOH1204 |
D | GLN59 |
A | THR76 |
A | ILE77 |
A | THR78 |
A | ARG83 |
A | ASN97 |
A | GLU308 |
A | HIS311 |
site_id | AC2 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE NAP B 1002 |
Chain | Residue |
B | LYS73 |
B | ALA75 |
B | THR76 |
B | ILE77 |
B | THR78 |
B | ASN97 |
B | GLU308 |
B | HIS311 |
B | GLY312 |
B | THR313 |
B | ARG316 |
B | HIS317 |
B | ASN330 |
B | HOH1014 |
B | HOH1067 |
B | HOH1181 |
site_id | AC3 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE NAP C 1003 |
Chain | Residue |
C | LYS73 |
C | ALA75 |
C | THR76 |
C | ILE77 |
C | THR78 |
C | ARG83 |
C | ASN97 |
C | GLU308 |
C | HIS311 |
C | GLY312 |
C | THR313 |
C | THR315 |
C | ARG316 |
C | HIS317 |
C | THR329 |
C | ASN330 |
C | HOH1033 |
C | HOH1053 |
C | HOH1154 |
C | HOH1208 |
site_id | AC4 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE NAP D 1004 |
Chain | Residue |
A | GLN59 |
D | LYS73 |
D | ALA75 |
D | THR76 |
D | ILE77 |
D | THR78 |
D | ARG83 |
D | ASN97 |
D | GLU308 |
D | HIS311 |
D | GLY312 |
D | THR313 |
D | THR315 |
D | ARG316 |
D | HIS317 |
D | THR329 |
D | ASN330 |
D | HOH1029 |
D | HOH1030 |
D | HOH1080 |
D | HOH1161 |
Functional Information from PROSITE/UniProt
site_id | PS00470 |
Number of Residues | 20 |
Details | IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NYDGDVqSDivAqgf.GSLGL |
Chain | Residue | Details |
A | ASN273-LEU292 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 44 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | THR76 | |
A | GLY312 | |
A | ASN330 | |
B | THR76 | |
B | THR78 | |
B | ARG83 | |
B | SER95 | |
B | ARG110 | |
B | ARG133 | |
B | ASP254 | |
B | LYS262 | |
A | THR78 | |
B | ASP277 | |
B | GLY312 | |
B | ASN330 | |
C | THR76 | |
C | THR78 | |
C | ARG83 | |
C | SER95 | |
C | ARG110 | |
C | ARG133 | |
C | ASP254 | |
A | ARG83 | |
C | LYS262 | |
C | ASP277 | |
C | GLY312 | |
C | ASN330 | |
D | THR76 | |
D | THR78 | |
D | ARG83 | |
D | SER95 | |
D | ARG110 | |
D | ARG133 | |
A | SER95 | |
D | ASP254 | |
D | LYS262 | |
D | ASP277 | |
D | GLY312 | |
D | ASN330 | |
A | ARG110 | |
A | ARG133 | |
A | ASP254 | |
A | LYS262 | |
A | ASP277 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | SITE: Critical for catalysis => ECO:0000250 |
Chain | Residue | Details |
A | TYR140 | |
A | LYS214 | |
B | TYR140 | |
B | LYS214 | |
C | TYR140 | |
C | LYS214 | |
D | TYR140 | |
D | LYS214 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1a05 |
Chain | Residue | Details |
A | VAL156 |
site_id | CSA10 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1a05 |
Chain | Residue | Details |
B | THR163 |
site_id | CSA11 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1a05 |
Chain | Residue | Details |
C | THR163 |
site_id | CSA12 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1a05 |
Chain | Residue | Details |
D | THR163 |
site_id | CSA2 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1a05 |
Chain | Residue | Details |
B | VAL156 |
site_id | CSA3 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1a05 |
Chain | Residue | Details |
C | VAL156 |
site_id | CSA4 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1a05 |
Chain | Residue | Details |
D | VAL156 |
site_id | CSA5 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a05 |
Chain | Residue | Details |
A | ASP254 | |
A | LYS214 |
site_id | CSA6 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a05 |
Chain | Residue | Details |
B | ASP254 | |
B | LYS214 |
site_id | CSA7 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a05 |
Chain | Residue | Details |
C | ASP254 | |
C | LYS214 |
site_id | CSA8 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a05 |
Chain | Residue | Details |
D | ASP254 | |
D | LYS214 |
site_id | CSA9 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1a05 |
Chain | Residue | Details |
A | THR163 |