2QDC

Crystal structure of the HePTP catalytic domain D236A mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Tyrosine-protein phosphatase non-receptor type 7	polymer	309	35292.0	1	UniProt (P35236) Pfam (PF00102)	Homo sapiens (human)	Protein-tyrosine phosphatase LC-PTP, Hematopoietic protein-tyrosine phosphatase, HEPTP
2	B, C (A)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
3	D, E (A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
4	F (A)	water	water		18.0	230	Chemie (HOH)

Sequence modifications

A: 44 - 339 (UniProt: P35236)

PDB	External Database	Details
Met -12	-	expression tag
Gly -11	-	expression tag
Ser -10	-	expression tag
Asp -9	-	expression tag
Lys -8	-	expression tag
Ile -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
Met 0	-	expression tag
Ala 236	Asp 257	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	35292.0
Non-Polymers*	Number of molecules	4
	Total formula weight	374.1
All*	Total formula weight	35666.1

*Water molecules are not included.