2QDC
Crystal structure of the HePTP catalytic domain D236A mutant
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein phosphatase non-receptor type 7 | polymer | 309 | 35292.0 | 1 | UniProt (P35236) Pfam (PF00102) In PDB | Homo sapiens (human) | Protein-tyrosine phosphatase LC-PTP, Hematopoietic protein-tyrosine phosphatase, HEPTP |
2 | A | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
3 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
4 | water | water | 18.0 | 230 | Chemie (HOH) |
Sequence modifications
A: 44 - 339 (UniProt: P35236)
PDB | External Database | Details |
---|---|---|
Met -12 | - | expression tag |
Gly -11 | - | expression tag |
Ser -10 | - | expression tag |
Asp -9 | - | expression tag |
Lys -8 | - | expression tag |
Ile -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
Met 0 | - | expression tag |
Ala 236 | Asp 257 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 35292.0 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 374.1 | |
All* | Total formula weight | 35666.1 |