2QDC

Crystal structure of the HePTP catalytic domain D236A mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0006470	biological_process	protein dephosphorylation
A	0016311	biological_process	dephosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 A 436

Chain	Residue
A	CYS270
A	HOH701
A	SER271
A	ALA272
A	GLY273
A	ILE274
A	GLY275
A	ARG276
A	GLN314
A	HOH503

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 A 437

Chain	Residue
A	THR174
A	GLN175
A	SER271
A	ARG276
A	HOH527
A	HOH533
A	HOH645

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 501

Chain	Residue
A	GLN112
A	GLU222
A	ARG223
A	ARG224
A	HOH632
A	HOH716
A	HOH728
A	HOH729

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 502

Chain	Residue
A	GLN112
A	SER113
A	TYR133
A	GLU141
A	HOH526
A	HOH531
A	HOH571
A	HOH647
A	HOH716
A	HOH728

---

Functional Information from PROSITE/UniProt

site_id	PS00383
Number of Residues	11
Details	TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGigRTG

Chain	Residue	Details
A	VAL268-GLY278

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044, ECO:0000269|PubMed:9624114

Chain	Residue	Details
A	CYS270

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
A	ALA236
A	CYS270
A	GLN314

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:10206983, ECO:0007744|PubMed:18088087, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR45

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:10206983

Chain	Residue	Details
A	SER72

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER89

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER122

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Cysteine sulfenic acid (-SOH) => ECO:0000250

Chain	Residue	Details
A	CYS270

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1d5r

Chain	Residue	Details
A	ARG276
A	CYS270

---