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2QCH

Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase bound to 5-iodo-UMP

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Uridine 5'-monophosphate synthase (UMP synthase)polymer26028299.72UniProt (P11172)
Pfam (PF00215)
Homo sapiens (human)
2C, F
(A, B)
IODIDE IONnon-polymer126.92Chemie (IOD)
3D, G
(A, B)
5-IODO-2'-DEOXYURIDINE-5'-MONOPHOSPHATEnon-polymer434.12Chemie (5IU)
4E, H
(A, B)
2'-DEOXYURIDINE 5'-MONOPHOSPHATEnon-polymer308.22Chemie (UMP)
5I, J
(A, B)
waterwater18.0229Chemie (HOH)
Sequence modifications
A, B: 224 - 480 (UniProt: P11172)
PDBExternal DatabaseDetails
Gly 221-expression tag
Ala 222-expression tag
Met 223-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight56599.5
Non-Polymers*Number of molecules6
Total formula weight1738.3
All*Total formula weight58337.8
*Water molecules are not included.

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PDB entries from 2025-07-30

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