2QCH

Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase bound to 5-iodo-UMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0044205	biological_process	'de novo' UMP biosynthetic process
B	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0044205	biological_process	'de novo' UMP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE IOD A 5

Chain	Residue
A	5IU1
A	UMP2
A	ASP312
A	LYS314
A	ASN341

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IOD B 6

Chain	Residue
B	5IU3
B	UMP4
B	ASP312
B	LYS314

---

site_id	AC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 5IU A 1

Chain	Residue
A	UMP2
A	IOD5
A	SER257
A	ASP259
A	LYS281
A	HIS283
A	LYS314
A	MET371
A	SER372
A	PRO417
A	GLN430
A	TYR432
A	GLY450
A	ARG451
A	HOH481
A	HOH485
B	ASP317
B	ILE318
B	THR321

---

site_id	AC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE UMP A 2

Chain	Residue
A	5IU1
A	IOD5
A	SER257
A	ASP259
A	LYS281
A	HIS283
A	LYS314
A	MET371
A	SER372
A	PRO417
A	GLN430
A	TYR432
A	GLY450
A	ARG451
A	HOH481
A	HOH485
A	HOH507
B	ASP317
B	ILE318
B	THR321

---

site_id	AC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE 5IU B 3

Chain	Residue
A	ASP317
A	THR321
B	UMP4
B	IOD6
B	SER257
B	ASP259
B	LYS281
B	HIS283
B	LYS314
B	ILE368
B	MET371
B	SER372
B	PRO417
B	GLN430
B	TYR432
B	VAL449
B	GLY450
B	ARG451
B	HOH482
B	HOH510

---

site_id	AC6
Number of Residues	19
Details	BINDING SITE FOR RESIDUE UMP B 4

Chain	Residue
A	ASP317
A	ILE318
A	THR321
B	5IU3
B	IOD6
B	SER257
B	ASP259
B	LYS281
B	HIS283
B	LYS314
B	MET371
B	SER372
B	PRO417
B	GLN430
B	TYR432
B	GLY450
B	ARG451
B	HOH482
B	HOH510

---

Functional Information from PROSITE/UniProt

site_id	PS00156
Number of Residues	14
Details	OMPDECASE Orotidine 5'-phosphate decarboxylase active site. IFeDrKfaDIGnTV

Chain	Residue	Details
A	ILE309-VAL322

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"For OMPdecase activity","evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QCD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QCD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QCH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QCL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1dbt

Chain	Residue	Details
A	LYS314
A	ASP312

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1dbt

Chain	Residue	Details
B	LYS314
B	ASP312

---

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1dbt

Chain	Residue	Details
A	LYS281
A	ASP317
A	LYS314
A	ASP312

---

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1dbt

Chain	Residue	Details
B	LYS281
B	ASP317
B	LYS314
B	ASP312

---