2QCD

Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase bound to UMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Uridine 5'-monophosphate synthase (UMP synthase)	polymer	260	28331.8	1	UniProt (P11172) Pfam (PF00215) In PDB	Homo sapiens (human)
2	B	Uridine 5'-monophosphate synthase (UMP synthase)	polymer	260	28299.7	1	UniProt (P11172) Pfam (PF00215) In PDB	Homo sapiens (human)
3	A, B	URIDINE-5'-MONOPHOSPHATE	non-polymer		324.2	2	Chemie (U5P)
4		water	water		18.0	348	Chemie (HOH)

Sequence modifications

A: 224 - 480 (UniProt: P11172)

PDB	External Database	Details
Gly 221	-	EXPRESSION TAG
Ala 222	-	EXPRESSION TAG
Met 223	-	EXPRESSION TAG

B: 224 - 480 (UniProt: P11172)

PDB	External Database	Details
Gly 221	-	EXPRESSION TAG
Ala 222	-	EXPRESSION TAG
Met 223	-	EXPRESSION TAG

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	56631.6
Non-Polymers*	Number of molecules	2
	Total formula weight	648.4
All*	Total formula weight	57279.9

*Water molecules are not included.