2QC1
Crystal structure of the extracellular domain of the nicotinic acetylcholine receptor 1 subunit bound to alpha-bungarotoxin at 1.9 A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Alpha-bungarotoxin | polymer | 74 | 8033.3 | 1 | UniProt (P60616) Pfam (PF21947) | Bungarus multicinctus (many-banded krait) | Alpha-BTX V31, BGTX V31, Alpha-BgtV31, Long neurotoxin 1 |
| 2 | B (B) | Acetylcholine receptor subunit alpha | polymer | 212 | 24729.0 | 1 | UniProt (P04756) Pfam (PF02931) | Mus musculus (house mouse) | |
| 3 | C (C) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1721.5 | 1 | In PDB GlyTouCan (G43111IG) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 187 | Chemie (HOH) |
Sequence modifications
B: 1 - 211 (UniProt: P04756)
| PDB | External Database | Details |
|---|---|---|
| Lys 0 | - | cloning artifact |
| Glu 8 | Val 28 | engineered mutation |
| Arg 149 | Trp 169 | engineered mutation |
| Ala 155 | Val 175 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 32762.3 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 1721.5 | |
| All* | Total formula weight | 34483.9 |
