2QB0
Structure of the 2TEL crystallization module fused to T4 lysozyme with an Ala-Gly-Pro linker.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Transcription factor ETV6 | polymer | 77 | 9252.5 | 2 | UniProt (P41212) Pfam (PF02198) | Homo sapiens | ETS translocation variant 6,ETS-related protein Tel1,Tel |
| 2 | B, D (B, D) | Transcription factor ETV6,Endolysin | polymer | 241 | 27720.8 | 2 | UniProt (P41212) UniProt (P00720) Pfam (PF00959) | Homo sapiens (human) | ETS translocation variant 6,ETS-related protein Tel1,Tel,Lysis protein,Lysozyme,Muramidase |
| 3 | E, F, G, H, I (B, C, D) | MANGANESE (II) ION | non-polymer | 54.9 | 5 | Chemie (MN) | |||
| 4 | J, K, L, M (A, B, C, D) | water | water | 18.0 | 147 | Chemie (HOH) |
Sequence modifications
A, C: 15 - 91 (UniProt: P41212)
B, D: 15 - 91 (UniProt: P41212)
B, D: 95 - 255 (UniProt: P00720)
| PDB | External Database | Details |
|---|---|---|
| Glu 80 | Val 112 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 92 | - | linker |
| Gly 93 | - | linker |
| Pro 94 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 105 | Arg 12 | conflict |
| Thr 147 | Cys 54 | conflict |
| Cys 161 | Asn 68 | conflict |
| Cys 186 | Ala 93 | conflict |
| Ala 190 | Cys 97 | conflict |
| Arg 230 | Ile 137 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 73946.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 274.7 | |
| All* | Total formula weight | 74221.3 |
